Version 5.4
Homo sapiens Gene: TRMT1L
Summary
InnateDB Gene IDBG-105374.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRMT1L
Gene Name tRNA methyltransferase 1 homolog (S. cerevisiae)-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000121486
Encoded Proteins
IDBP-105376
TRM1 tRNA methyltransferase 1-like
IDBP-389808
TRM1 tRNA methyltransferase 1-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that has some similarity to N2,N2-dimethylguanosine tRNA methyltransferase from other organisms. Studies of the mouse ortholog have shown that this protein plays a role in motor coordination and exploratory behavior, and it may also be involved in modulating postnatal neuronal functions. Alternatively spliced transcripts have been identified for this gene. [provided by RefSeq, Jan 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:185118098-185157072
Strand Reverse strand
Band q25.3
Transcripts
ENST00000367506 ENSP00000356476
ENST00000458395 ENSP00000414339
ENST00000465827
ENST00000487028
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0004809 tRNA (guanine-N2-)-methyltransferase activity
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0008033 tRNA processing
GO:0008344 adult locomotory behavior
GO:0030488 tRNA methylation
GO:0030534 adult behavior
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000053286
View Gene Order
ENSBTAG00000011285
Not yet available
Cross-References
SwissProt Q7Z2T5
TrEMBL
UniProt Splice Variant
Entrez Gene 81627
UniGene Hs.107149 Hs.602943 Hs.719468
RefSeq NM_001202423 NM_030934
HUGO HGNC:16782
OMIM 611673
CCDS CCDS1366
HPRD 12722
IMGT
EMBL AF163261 AF288399 AK074936 AK074993 AK131460 AL109865 AL136133 BC039738 BC045535 CH471067
GenPept AAG60618 AAH39738 AAH45535 AAQ13590 BAC11302 BAC11341 BAD18605 CAI17847 CAI17851 CAI17938 EAW91190
RNA Seq Atlas 81627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca