Version 5.4
| Homo sapiens Gene: TNNI1 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-105757.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | TNNI1 | ||||||||||||||||||
| Gene Name | troponin I type 1 (skeletal, slow) | ||||||||||||||||||
| Synonyms | SSTNI; TNN1 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000159173 | ||||||||||||||||||
| Encoded Proteins |
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:201403768-201429866 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q32.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Striated Muscle Contraction pathway
Muscle contraction pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | G3V489 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 7135 | ||||||||||||||||||
| UniGene | Hs.320890 Hs.624052 | ||||||||||||||||||
| RefSeq | NM_003281 | ||||||||||||||||||
| HUGO | HGNC:11945 | ||||||||||||||||||
| OMIM | 191042 | ||||||||||||||||||
| CCDS | CCDS1411 | ||||||||||||||||||
| HPRD | 01842 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC096677 | ||||||||||||||||||
| GenPept | |||||||||||||||||||
| RNA Seq Atlas | 7135 | ||||||||||||||||||