Homo sapiens Gene: TNNI1
Summary
InnateDB Gene IDBG-105757.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TNNI1
Gene Name troponin I type 1 (skeletal, slow)
Synonyms SSTNI; TNN1;
Species Homo sapiens
Ensembl Gene ENSG00000159173
Encoded Proteins
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
troponin I type 1 (skeletal, slow)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Troponin proteins associate with tropomyosin and regulate the calcium sensitivity of the myofibril contractile apparatus of striated muscles. Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. The TnI-fast and TnI-slow genes are expressed in fast-twitch and slow-twitch skeletal muscle fibers, respectively, while the TnI-cardiac gene is expressed exclusively in cardiac muscle tissue. This gene encodes the Troponin-I-skeletal-slow-twitch protein. This gene is expressed in cardiac and skeletal muscle during early development but is restricted to slow-twitch skeletal muscle fibers in adults. The encoded protein prevents muscle contraction by inhibiting calcium-mediated conformational changes in actin-myosin complexes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:201403768-201429866
Strand Reverse strand
Band q32.1
Transcripts
ENST00000361379 ENSP00000354488
ENST00000336092 ENSP00000337022
ENST00000367312 ENSP00000356281
ENST00000555948 ENSP00000451307
ENST00000555340 ENSP00000451660
ENST00000556362 ENSP00000451776
ENST00000622580 ENSP00000477578
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0046872 metal ion binding
Biological Process
GO:0006942 regulation of striated muscle contraction
GO:0030049 muscle filament sliding
GO:0055010 ventricular cardiac muscle tissue morphogenesis
Cellular Component
GO:0005829 cytosol
GO:0005861 troponin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
REACTOME
Muscle contraction pathway
Striated Muscle Contraction pathway
KEGG
INOH
PID BIOCARTA
Actions of nitric oxide in the heart [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL G3V489
UniProt Splice Variant
Entrez Gene 7135
UniGene Hs.320890 Hs.624052
RefSeq NM_003281
HUGO HGNC:11945
OMIM 191042
CCDS CCDS1411
HPRD 01842
IMGT
EMBL AC096677
GenPept
RNA Seq Atlas 7135