Version 5.4
Homo sapiens Gene: UBE2T
Summary
InnateDB Gene IDBG-105843.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UBE2T
Gene Name ubiquitin-conjugating enzyme E2T (putative)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000077152
Encoded Proteins
IDBP-105845
ubiquitin-conjugating enzyme E2T (putative)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The covalent conjugation of ubiquitin to proteins regulates diverse cellular pathways and proteins. Ubiquitin is transferred to a target protein through a concerted action of a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), such as UBE2T, and a ubiquitin ligase (E3) (Machida et al., 2006 [PubMed 16916645]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:202331657-202341980
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367274 ENSP00000356243
ENST00000487227
ENST00000460852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004842 ubiquitin-protein transferase activity
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
GO:0031625 ubiquitin protein ligase binding
Biological Process
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0006974 cellular response to DNA damage stimulus
GO:0035519 protein K29-linked ubiquitination
GO:0044314 protein K27-linked ubiquitination
GO:0051865 protein autoubiquitination
GO:0070534 protein K63-linked ubiquitination
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
GO:0085020 protein K6-linked ubiquitination
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000026429
View Gene Order
ENSBTAG00000004790
Not yet available
Pathways
NETPATH
REACTOME
REACT_18410
Fanconi Anemia pathway pathway
REACT_216
DNA Repair pathway
KEGG
INOH
PID NCI
fanconi_pathway
Fanconi anemia pathway
Cross-References
SwissProt Q9NPD8
TrEMBL A0A024R9A9
UniProt Splice Variant
Entrez Gene 29089
UniGene
RefSeq NM_014176
HUGO HGNC:25009
OMIM 610538
CCDS CCDS1425
HPRD
IMGT
EMBL AB032931 AF160215 AF161499 AK000504 AL356953 AY542309 BC004152 BC019284 CH471067
GenPept AAF29114 AAF67016 AAH04152 AAH19284 AAT08178 BAA91211 BAA93711 CAI15933 EAW91411 EAW91415
RNA Seq Atlas 29089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca