Homo sapiens Gene: CHIT1
Summary
InnateDB Gene IDBG-105936.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHIT1
Gene Name chitinase 1 (chitotriosidase)
Synonyms CHI3; CHIT; CHITD;
Species Homo sapiens
Ensembl Gene ENSG00000133063
Encoded Proteins
chitinase 1 (chitotriosidase)
chitinase 1 (chitotriosidase)
chitinase 1 (chitotriosidase)
chitinase 1 (chitotriosidase)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Chitotriosidase is secreted by activated human macrophages and is markedly elevated in plasma of Gaucher disease patients. The expression of chitotriosidase occurs only at a late stage of differentiation of monocytes to activated macrophages in culture. Human macrophages can synthesize a functional chitotriosidase, a highly conserved enzyme with a strongly regulated expression. This enzyme may play a role in the degradation of chitin-containing pathogens. Several alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jan 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:203212827-203273641
Strand Reverse strand
Band q32.1
Transcripts
ENST00000367229 ENSP00000356198
ENST00000255427 ENSP00000255427
ENST00000484834
ENST00000479483
ENST00000491855 ENSP00000423778
ENST00000503786 ENSP00000421617
ENST00000506427
ENST00000513472
ENST00000460619
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds
GO:0004568 chitinase activity
GO:0008061 chitin binding
GO:0008843 endochitinase activity
Biological Process
GO:0000272 polysaccharide catabolic process
GO:0005975 carbohydrate metabolic process
GO:0006030 chitin metabolic process
GO:0006032 chitin catabolic process
GO:0006955 immune response
GO:0009617 response to bacterium
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005764 lysosome
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
KEGG
Amino sugar and nucleotide sugar metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.201688 Hs.735381
RefSeq NM_001256125 NM_001270509 NM_003465
HUGO
OMIM
CCDS CCDS1436 CCDS58057
HPRD 02494
IMGT
EMBL
GenPept
RNA Seq Atlas