InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: CD34

Summary

InnateDB Gene

IDBG-638449.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CD34

Gene Name

hematopoietic progenitor cell antigen CD34 precursor

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000010562

Encoded Proteins

IDBP-690525

hematopoietic progenitor cell antigen CD34

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000174059:
The protein encoded by this gene may play a role in the attachment of stem cells to the bone marrow extracellular matrix or to stromal cells. This single-pass membrane protein is highly glycosylated and phosphorylated by protein kinase C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:77367502-77389361

Strand

Forward strand

Band

Transcripts

ENSBTAT00000013963

ENSBTAP00000013963

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008134	transcription factor binding
GO:0030246	carbohydrate binding
GO:0043199	sulfate binding

Biological Process

GO:0001894	tissue homeostasis
GO:0001935	endothelial cell proliferation
GO:0003094	glomerular filtration
GO:0003158	endothelium development
GO:0006536	glutamate metabolic process
GO:0007155	cell adhesion
GO:0007165	signal transduction
GO:0008217	regulation of blood pressure
GO:0010628	positive regulation of gene expression
GO:0010629	negative regulation of gene expression
GO:0016337	single organismal cell-cell adhesion
GO:0030097	hemopoiesis
GO:0030195	negative regulation of blood coagulation
GO:0032720	negative regulation of tumor necrosis factor production
GO:0032733	positive regulation of interleukin-10 production
GO:0038001	paracrine signaling
GO:0042482	positive regulation of odontogenesis
GO:0045019	negative regulation of nitric oxide biosynthetic process
GO:0045766	positive regulation of angiogenesis
GO:0048870	cell motility
GO:0050900	leukocyte migration
GO:0060290	transdifferentiation
GO:0061042	vascular wound healing
GO:0071425	hematopoietic stem cell proliferation
GO:0071636	positive regulation of transforming growth factor beta production
GO:0071657	positive regulation of granulocyte colony-stimulating factor production
GO:0071971	extracellular vesicular exosome assembly
GO:0072011	glomerular endothelium development
GO:0072089	stem cell proliferation
GO:0072254	metanephric glomerular mesangial cell differentiation
GO:1900035	negative regulation of cellular response to heat
GO:1900038	negative regulation of cellular response to hypoxia
GO:1900041	negative regulation of interleukin-2 secretion
GO:1900168	positive regulation of glial cell line-derived neurotrophic factor secretion
GO:1901215	negative regulation of neuron death
GO:2001214	positive regulation of vasculogenesis

Cellular Component

GO:0005576	extracellular region
GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0045171	intercellular bridge
GO:0048471	perinuclear region of cytoplasm
GO:0071944	cell periphery