InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYT14

Summary

InnateDB Gene

IDBG-106460.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT14

Gene Name

synaptotagmin XIV

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000143469

Encoded Proteins

IDBP-106462

synaptotagmin XIV

IDBP-106468

synaptotagmin XIV

IDBP-599188

synaptotagmin XIV

IDBP-479213

synaptotagmin XIV

IDBP-583383

synaptotagmin XIV

IDBP-593406

synaptotagmin XIV

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate membrane trafficking in synaptic transmission. The encoded protein is a calcium-independent synaptotagmin. Mutations in this gene are a cause of autosomal recessive spinocerebellar ataxia-11 (SCAR11), and a t(1;3) translocation of this gene has been associated with neurodevelopmental abnormalities. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 4. [provided by RefSeq, Dec 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 1:209938174-210171315

Strand

Forward strand

Band

q32.2

Transcripts

ENST00000367019	ENSP00000355986
ENST00000367015	ENSP00000355982
ENST00000399639	ENSP00000445837
ENST00000472886	ENSP00000418901
ENST00000534859	ENSP00000442891
ENST00000537238	ENSP00000437423

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005543	phospholipid binding
GO:0042803	protein homodimerization activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0008219

cell death

Cellular Component

GO:0016021

integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000016200

View Gene Order

ENSBTAG00000046723

Not yet available

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.630129 Hs.658866

RefSeq

NM_001146261 NM_001146262 NM_001146264 NM_001256006 NM_153262 XM_006711264

HUGO

OMIM

CCDS

CCDS31014 CCDS53470 CCDS58058

HPRD

11617

IMGT

EMBL

GenPept

RNA Seq Atlas