Homo sapiens Gene: HIBADH
Summary
InnateDB Gene IDBG-10662.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HIBADH
Gene Name 3-hydroxyisobutyrate dehydrogenase
Synonyms NS5ATP1;
Species Homo sapiens
Ensembl Gene ENSG00000106049
Encoded Proteins
3-hydroxyisobutyrate dehydrogenase
3-hydroxyisobutyrate dehydrogenase
3-hydroxyisobutyrate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:27525442-27662995
Strand Reverse strand
Band p15.2
Transcripts
ENST00000265395 ENSP00000265395
ENST00000428288 ENSP00000393365
ENST00000425715 ENSP00000390205
ENST00000496814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
GO:0051287 NAD binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0006574 valine catabolic process
GO:0009083 branched-chain amino acid catabolic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Branched-chain amino acid catabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
KEGG
Valine, leucine and isoleucine degradation pathway
INOH
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F8WET2
UniProt Splice Variant
Entrez Gene 11112
UniGene Hs.599452
RefSeq NM_152740
HUGO HGNC:4907
OMIM 608475
CCDS CCDS5414
HPRD 12238
IMGT
EMBL AC005091 AC007130
GenPept
RNA Seq Atlas 11112