Mus musculus Gene: Hibadh
Summary
InnateDB Gene IDBG-148236.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hibadh
Gene Name 3-hydroxyisobutyrate dehydrogenase
Synonyms 6430402H10Rik; AI265272;
Species Mus musculus
Ensembl Gene ENSMUSG00000029776
Encoded Proteins
3-hydroxyisobutyrate dehydrogenase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000106049:
This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:52546228-52640389
Strand Reverse strand
Band B3
Transcripts
ENSMUST00000031788 ENSMUSP00000031788
ENSMUST00000155948
ENSMUST00000149471
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 12 [view]
Protein-Protein 12 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008442 3-hydroxyisobutyrate dehydrogenase activity
GO:0051287 NAD binding
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0006574 valine catabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Branched-chain amino acid catabolism pathway
KEGG
Valine, leucine and isoleucine degradation pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Branched-chain amino acid catabolism pathway
Metabolism of amino acids and derivatives pathway
Metabolism pathway
Metabolism of amino acids and derivatives pathway
Branched-chain amino acid catabolism pathway
Metabolism pathway
KEGG
Valine, leucine and isoleucine degradation pathway
INOH
Valine Leucine Isoleucine degradation pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.474033
RefSeq NM_145567
OMIM
CCDS CCDS20151
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas