Version 5.4
Homo sapiens Gene: ITPKB
Summary
InnateDB Gene IDBG-107048.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ITPKB
Gene Name inositol-trisphosphate 3-kinase B
Synonyms IP3-3KB; IP3K; IP3K-B; IP3KB; PIG37
Species Homo sapiens
Ensembl Gene ENSG00000143772
Encoded Proteins
IDBP-107050
inositol-trisphosphate 3-kinase B
IDBP-107052
inositol-trisphosphate 3-kinase B
IDBP-390084
inositol-trisphosphate 3-kinase B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:226631690-226739323
Strand Reverse strand
Band q42.12
Transcripts
ENST00000272117 ENSP00000272117
ENST00000366784 ENSP00000355748
ENST00000429204 ENSP00000411152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity
Biological Process
GO:0000165 MAPK cascade
GO:0007165 signal transduction
GO:0007166 cell surface receptor signaling pathway
GO:0030217 T cell differentiation
GO:0043647 inositol phosphate metabolic process
GO:0044281 small molecule metabolic process
GO:0045059 positive thymic T cell selection
GO:0045061 thymic T cell selection
GO:0046579 positive regulation of Ras protein signal transduction
GO:0046638 positive regulation of alpha-beta T cell differentiation
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038855
View Gene Order
ENSBTAG00000019339
Not yet available
Pathways
NETPATH
REACTOME
REACT_150312
Synthesis of IP3 and IP4 in the cytosol pathway
REACT_150154
Inositol phosphate metabolism pathway
REACT_111217
Metabolism pathway
KEGG
hsa00562
Inositol phosphate metabolism pathway
hsa04070
Phosphatidylinositol signaling system pathway
hsa04020
Calcium signaling pathway pathway
INOH
INOH website
Inositol phosphate metabolism pathway
PID NCI
Cross-References
SwissProt P27987
TrEMBL
UniProt Splice Variant
Entrez Gene 3707
UniGene Hs.528087 Hs.743604
RefSeq NM_002221 XM_005273120
HUGO HGNC:6179
OMIM 147522
CCDS CCDS1555
HPRD 00942
IMGT
EMBL AJ242780 AL365444 BC015009 X57206 Y18024
GenPept AAH15009 CAA40491 CAB65055 CAC40650 CAH70187 CAH70188
RNA Seq Atlas 3707

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca