Bos taurus Gene: GGCT
Summary
InnateDB Gene IDBG-633436.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGCT
Gene Name Gamma-glutamylcyclotransferase
Synonyms C7orf24;
Species Bos taurus
Ensembl Gene ENSBTAG00000010597
Encoded Proteins
Gamma-glutamylcyclotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006625:
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:66204846-66214292
Strand Forward strand
Band
Transcripts
ENSBTAT00000014010 ENSBTAP00000014010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Glutathione conjugation pathway
Biological oxidations pathway
Glutathione synthesis and recycling pathway
Metabolism pathway
Phase II conjugation pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Glutathione conjugation pathway
Glutathione synthesis and recycling pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
Phase II conjugation pathway
Metabolism pathway
Glutathione conjugation pathway
Glutathione synthesis and recycling pathway
Biological oxidations pathway
KEGG
Glutathione metabolism pathway
Glutathione metabolism pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.109947
RefSeq NM_001037610
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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