Version 5.4
Bos taurus Gene: GGCT
Summary
InnateDB Gene IDBG-633436.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GGCT
Gene Name Gamma-glutamylcyclotransferase
Synonyms C7orf24
Species Bos taurus
Ensembl Gene ENSBTAG00000010597
Encoded Proteins
IDBP-685146
Gamma-glutamylcyclotransferase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000006625:
The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:66204846-66214292
Strand Forward strand
Band
Transcripts
ENSBTAT00000014010 ENSBTAP00000014010
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003839 gamma-glutamylcyclotransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
GO:0042803 protein homodimerization activity
Biological Process
GO:0001836 release of cytochrome c from mitochondria
GO:0006750 glutathione biosynthetic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000006625
View Gene Order
ENSMUSG00000002797
View Gene Order
Pathways
NETPATH
REACTOME
REACT_223659
Glutathione conjugation pathway
REACT_218176
Biological oxidations pathway
REACT_227316
Glutathione synthesis and recycling pathway
REACT_219139
Metabolism pathway
REACT_213008
Phase II conjugation pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_6960
Glutathione synthesis and recycling pathway
REACT_6926
Glutathione conjugation pathway
REACT_6959
Phase II conjugation pathway
REACT_111217
Metabolism pathway
REACT_13433
Biological oxidations pathway
REACT_243247
Phase II conjugation pathway
REACT_188937
Metabolism pathway
REACT_215316
Glutathione conjugation pathway
REACT_210980
Glutathione synthesis and recycling pathway
REACT_232343
Biological oxidations pathway
KEGG
hsa00480
Glutathione metabolism pathway
mmu00480
Glutathione metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.109947
RefSeq NM_001037610
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca