Version 5.4
Homo sapiens Gene: ZFYVE1
Summary
InnateDB Gene IDBG-11183.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFYVE1
Gene Name zinc finger, FYVE domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000165861
Encoded Proteins
IDBP-11185
zinc finger, FYVE domain containing 1
IDBP-242035
zinc finger, FYVE domain containing 1
IDBP-592815
zinc finger, FYVE domain containing 1
IDBP-590499
zinc finger, FYVE domain containing 1
IDBP-587096
zinc finger, FYVE domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate (PtdIns(3)P)-containing membranes. This gene encodes a protein which contains two zinc-binding FYVE domains in tandem. This protein displays a predominantly Golgi, endoplasmic reticulum and vesicular distribution. Alternatively spliced transcript variants have been found for this gene, and they encode two isoforms with different sizes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:72969451-73027212
Strand Reverse strand
Band q24.2
Transcripts
ENST00000318876 ENSP00000326921
ENST00000394207 ENSP00000377757
ENST00000553891 ENSP00000452442
ENST00000556143 ENSP00000450742
ENST00000555072 ENSP00000452232
ENST00000556040
ENST00000556761
ENST00000554145
ENST00000554250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005545 1-phosphatidylinositol binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008270 zinc ion binding
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding
GO:0046872 metal ion binding
Biological Process
GO:0010923 negative regulation of phosphatase activity
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005795 Golgi stack
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042628
View Gene Order
ENSBTAG00000011041
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.335106
RefSeq NM_001281734 NM_001281735 NM_021260 NM_178441
HUGO
OMIM
CCDS CCDS41969 CCDS61498 CCDS9811
HPRD 12017
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca