Version 5.4
Homo sapiens Gene: CEP76
Summary
InnateDB Gene IDBG-1159.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CEP76
Gene Name centrosomal protein 76kDa
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101624
Encoded Proteins
IDBP-1161
centrosomal protein 76kDa
IDBP-363936
centrosomal protein 76kDa
IDBP-725728
IDBP-725816
IDBP-727691
IDBP-725677
IDBP-725805
IDBP-725583
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a centrosomal protein which regulates centriole amplification by limiting centriole duplication to once per cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:12661833-12702777
Strand Reverse strand
Band p11.21
Transcripts
ENST00000262127 ENSP00000262127
ENST00000423709 ENSP00000403074
ENST00000591034 ENSP00000467361
ENST00000590143 ENSP00000464760
ENST00000589490
ENST00000589875
ENST00000592660
ENST00000587666 ENSP00000464911
ENST00000587929 ENSP00000466833
ENST00000585751 ENSP00000467224
ENST00000593250 ENSP00000466689
ENST00000586887
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 111 experimentally validated interaction(s) in this database.
Experimentally validated
Total 111 [view]
Protein-Protein 111 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0046599 regulation of centriole replication
Cellular Component
GO:0005813 centrosome
GO:0005814 centriole
GO:0005829 cytosol
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073542
View Gene Order
ENSBTAG00000010547
Not yet available
Pathways
NETPATH
REACTOME
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_15364
Loss of Nlp from mitotic centrosomes pathway
REACT_15451
Loss of proteins required for interphase microtubule organization� from the centrosome pathway
REACT_15296
Recruitment of mitotic centrosome proteins and complexes pathway
REACT_115566
Cell Cycle pathway
REACT_15479
Centrosome maturation pathway
REACT_2203
G2/M Transition pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_21391
Mitotic G2-G2/M phases pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.236940 Hs.733687
RefSeq NM_001271989 NM_024899 XM_005258149 XM_006722356
HUGO
OMIM
CCDS CCDS11861 CCDS62390
HPRD 12694
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca