Homo sapiens Gene: ADCY2
Summary
InnateDB Gene IDBG-11792.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADCY2
Gene Name adenylate cyclase 2 (brain)
Synonyms AC2; HBAC2;
Species Homo sapiens
Ensembl Gene ENSG00000078295
Encoded Proteins
adenylate cyclase 2 (brain)
adenylate cyclase 2 (brain)
adenylate cyclase 2 (brain)
adenylate cyclase 2 (brain)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the family of adenylate cyclases, which are membrane-associated enzymes that catalyze the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This enzyme is insensitive to Ca(2+)/calmodulin, and is stimulated by the G protein beta and gamma subunit complex. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:7396208-7830081
Strand Forward strand
Band p15.31
Transcripts
ENST00000382531
ENST00000338316 ENSP00000342952
ENST00000484965
ENST00000498598
ENST00000515681 ENSP00000425069
ENST00000513693
ENST00000493243 ENSP00000426196
ENST00000489501
ENST00000537121 ENSP00000444803
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004016 adenylate cyclase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008179 adenylate cyclase binding
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
GO:0016849 phosphorus-oxygen lyase activity
GO:0031683 G-protein beta/gamma-subunit complex binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0006112 energy reserve metabolic process
GO:0006171 cAMP biosynthetic process
GO:0006833 water transport
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007188 adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007193 adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007268 synaptic transmission
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0009190 cyclic nucleotide biosynthetic process
GO:0034199 activation of protein kinase A activity
GO:0035556 intracellular signal transduction
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0055085 transmembrane transport
GO:0071377 cellular response to glucagon stimulus
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030425 dendrite
GO:0043234 protein complex
GO:0045121 membrane raft
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (s) signalling events pathway
Signaling by FGFR in disease pathway
Integration of energy metabolism pathway
Transmembrane transport of small molecules pathway
Adenylate cyclase activating pathway pathway
CaM pathway pathway
Signalling by NGF pathway
Vasopressin regulates renal water homeostasis via Aquaporins pathway
PKA-mediated phosphorylation of CREB pathway
Signaling by Hedgehog pathway
Signaling by EGFR in Cancer pathway
Downstream signaling of activated FGFR pathway
Phospholipase C-mediated cascade pathway
Adenylate cyclase inhibitory pathway pathway
DAP12 signaling pathway
Neuronal System pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Innate Immune System pathway
PLC beta mediated events pathway
GABA receptor activation pathway
Glucagon signaling in metabolic regulation pathway
PLC-gamma1 signalling pathway
Opioid Signalling pathway
Activation of GABAB receptors pathway
DAG and IP3 signaling pathway
PKA activation pathway
Signal Transduction pathway
GPCR downstream signaling pathway
G alpha (i) signalling events pathway
Hedgehog 'off' state pathway
G-protein mediated events pathway
Immune System pathway
Downstream signal transduction pathway
G alpha (z) signalling events pathway
GABA B receptor activation pathway
NGF signalling via TRKA from the plasma membrane pathway
Transmission across Chemical Synapses pathway
Signaling by FGFR pathway
Signaling by PDGF pathway
PKA activation in glucagon signalling pathway
Signaling by ERBB2 pathway
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
Metabolism pathway
Inhibition of adenylate cyclase pathway pathway
PLCG1 events in ERBB2 signaling pathway
Ca-dependent events pathway
Calmodulin induced events pathway
Aquaporin-mediated transport pathway
Disease pathway
DAP12 interactions pathway
EGFR interacts with phospholipase C-gamma pathway
KEGG
Purine metabolism pathway
Calcium signaling pathway pathway
Chemokine signaling pathway pathway
Oocyte meiosis pathway
Vascular smooth muscle contraction pathway
Gap junction pathway
GnRH signaling pathway pathway
Progesterone-mediated oocyte maturation pathway
Melanogenesis pathway
Salivary secretion pathway
Gastric acid secretion pathway
Pancreatic secretion pathway
Bile secretion pathway
Dilated cardiomyopathy pathway
INOH
GPCR signaling pathway
GPCR Adenosine A2A receptor signaling pathway pathway
Purine nucleotides nucleosides metabolism pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL D6REB8 Q71UM8
UniProt Splice Variant
Entrez Gene 108
UniGene Hs.481545 Hs.685649
RefSeq NM_020546
HUGO HGNC:233
OMIM 103071
CCDS CCDS3872
HPRD 00052
IMGT
EMBL AC010346 AC010437 AC024577 AC093305 AC113366 AF070583
GenPept AAC28647
RNA Seq Atlas 108