Homo sapiens Gene: SOD3
Summary
InnateDB Gene IDBG-11874.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOD3
Gene Name superoxide dismutase 3, extracellular
Synonyms EC-SOD;
Species Homo sapiens
Ensembl Gene ENSG00000109610
Encoded Proteins
superoxide dismutase 3, extracellular
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the superoxide dismutase (SOD) protein family. SODs are antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen. The product of this gene is thought to protect the brain, lungs, and other tissues from oxidative stress. The protein is secreted into the extracellular space and forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen. A fraction of the protein is cleaved near the C-terminus before secretion to generate circulating tetramers that do not interact with the ECM. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:24789912-24800842
Strand Forward strand
Band p15.2
Transcripts
ENST00000382120 ENSP00000371554
ENST00000598411 ENSP00000472134
ENST00000593742
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004784 superoxide dismutase activity
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0001666 response to hypoxia
GO:0006801 superoxide metabolic process
GO:0006979 response to oxidative stress
GO:0019430 removal of superoxide radicals
GO:0046688 response to copper ion
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005796 Golgi lumen
GO:0005802 trans-Golgi network
GO:0031012 extracellular matrix
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID BIOCARTA
Cardiac protection against ros [Biocarta view]
The igf-1 receptor and longevity [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.628252
RefSeq NM_003102
HUGO
OMIM
CCDS CCDS3430
HPRD 01708
IMGT
EMBL
GenPept
RNA Seq Atlas