Version 5.4
Homo sapiens Gene: NLRC3
Summary
InnateDB Gene IDBG-12133.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRC3
Gene Name NLR family, CARD domain containing 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167984
Encoded Proteins
IDBP-12137
NLR family, CARD domain containing 3
IDBP-12139
NLR family, CARD domain containing 3
IDBP-366766
NLR family, CARD domain containing 3
IDBP-807289
NLR family, CARD domain containing 3
IDBP-807292
NLR family, CARD domain containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22863753
NLRC3 inhibits Toll-like receptor (TLR)-dependent activation of NF-kB by interacting with the TLR signalling adaptor TRAF6 to attenuate ubiquitination of TRAF6 and activation of NF-kB. (Demonstrated in mouse)
InnateDB Annotation from Orthologs
Summary
PMID 22863753
[Mus musculus] Nlrc3 inhibits Toll-like receptor (TLR)-dependent activation of NF-kB by interacting with the TLR signalling adaptor Traf6 to attenuate ubiquitination of Traf6 and activation of NF-kB.
Entrez Gene
Summary The protein encoded by this gene is a cytosolic regulator of innate immunity. The encoded protein contains several leucine-rich repeat domains and may be involved in regulating T-cell activation. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Feb 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:3539033-3577400
Strand Reverse strand
Band p13.3
Transcripts
ENST00000359128 ENSP00000352039
ENST00000324659 ENSP00000323897
ENST00000448023 ENSP00000414415
ENST00000615877 ENSP00000482989
ENST00000618137 ENSP00000482302
ENST00000603055
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0005524 ATP binding
Biological Process
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0031396 regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032496 response to lipopolysaccharide
GO:0042110 T cell activation
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000049871
View Gene Order
ENSBTAG00000004505
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 197358
UniGene
RefSeq NM_178844
HUGO HGNC:29889
OMIM 615648
CCDS CCDS73817
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas 197358

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca