Mus musculus Gene: Ghr
Summary
InnateDB Gene IDBG-127871.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ghr
Gene Name growth hormone receptor
Synonyms GHBP; GHR/BP;
Species Mus musculus
Ensembl Gene ENSMUSG00000055737
Encoded Proteins
growth hormone receptor
growth hormone receptor
growth hormone receptor
growth hormone receptor
growth hormone receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000112964:
This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:3317760-3583492
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000069451 ENSMUSP00000069457
ENSMUST00000110698 ENSMUSP00000106326
ENSMUST00000110697 ENSMUSP00000106325
ENSMUST00000161561 ENSMUSP00000124064
ENSMUST00000161770 ENSMUSP00000125044
ENSMUST00000160343
ENSMUST00000162993
ENSMUST00000159508
ENSMUST00000161180
ENSMUST00000159912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 38 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004903 growth hormone receptor activity
GO:0005515 protein binding
GO:0017046 peptide hormone binding
GO:0019838 growth factor binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0042169 SH2 domain binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000187 activation of MAPK activity
GO:0000255 allantoin metabolic process
GO:0006101 citrate metabolic process
GO:0006103 2-oxoglutarate metabolic process
GO:0006105 succinate metabolic process
GO:0006107 oxaloacetate metabolic process
GO:0006549 isoleucine metabolic process
GO:0006573 valine metabolic process
GO:0006600 creatine metabolic process
GO:0006631 fatty acid metabolic process
GO:0006897 endocytosis
GO:0007259 JAK-STAT cascade
GO:0009725 response to hormone
GO:0009755 hormone-mediated signaling pathway
GO:0019221 cytokine-mediated signaling pathway
GO:0019530 taurine metabolic process
GO:0031623 receptor internalization
GO:0032094 response to food
GO:0032355 response to estradiol
GO:0032869 cellular response to insulin stimulus
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0040014 regulation of multicellular organism growth
GO:0040018 positive regulation of multicellular organism growth
GO:0042976 activation of Janus kinase activity
GO:0042977 activation of JAK2 kinase activity
GO:0043278 response to morphine
GO:0043434 response to peptide hormone
GO:0044236 multicellular organismal metabolic process
GO:0045597 positive regulation of cell differentiation
GO:0046427 positive regulation of JAK-STAT cascade
GO:0046449 creatinine metabolic process
GO:0046898 response to cycloheximide
GO:0048009 insulin-like growth factor receptor signaling pathway
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051384 response to glucocorticoid
GO:0060351 cartilage development involved in endochondral bone morphogenesis
GO:0060396 growth hormone receptor signaling pathway
GO:0070555 response to interleukin-1
GO:1901215 negative regulation of neuron death
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0019898 extrinsic component of membrane
GO:0043025 neuronal cell body
GO:0043235 receptor complex
GO:0070195 growth hormone receptor complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Nuclear signaling by ERBB4 pathway
Prolactin receptor signaling pathway
Signaling by ERBB4 pathway
Cytokine Signaling in Immune system pathway
Immune System pathway
Growth hormone receptor signaling pathway
Signal Transduction pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Cytokine Signaling in Immune system pathway
Signaling by ERBB4 pathway
Signal Transduction pathway
Prolactin receptor signaling pathway
Immune System pathway
Growth hormone receptor signaling pathway
Nuclear signaling by ERBB4 pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Neuroactive ligand-receptor interaction pathway
Jak-STAT signaling pathway pathway
INOH
JAK STAT pathway and regulation pathway
Growth hormone signaling pathway
PID BIOCARTA
Trefoil factors initiate mucosal healing [Biocarta view]
Regulation of eif-4e and p70s6 kinase [Biocarta view]
Mtor signaling pathway [Biocarta view]
Growth hormone signaling pathway [Biocarta view]
Akt signaling pathway [Biocarta view]
PID NCI
Notch-mediated HES/HEY network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3986 Mm.412708
RefSeq NM_001048147 NM_001048178 NM_001286370 NM_010284 XM_006519963 XM_006519964 XM_006519965 XM_006519966
OMIM
CCDS CCDS27358 CCDS37024
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas