InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Oxct1

Summary

InnateDB Gene

IDBG-127912.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Oxct1

Gene Name

3-oxoacid CoA transferase 1

Synonyms

2610008O03Rik; Oxct; Oxct2a; Scot-s

Species

Mus musculus

Ensembl Gene

ENSMUSG00000022186

Encoded Proteins

IDBP-259724

3-oxoacid CoA transferase 1

IDBP-532519

3-oxoacid CoA transferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000083720:
This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:4026383-4155344

Strand

Forward strand

Band

Transcripts

ENSMUST00000110690	ENSMUSP00000106318
ENSMUST00000138927	ENSMUSP00000116343
ENSMUST00000131240
ENSMUST00000124591
ENSMUST00000133130

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 12 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Experimentally validated
Total	12 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008260	3-oxoacid CoA-transferase activity
GO:0008410	CoA-transferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007420	brain development
GO:0007507	heart development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009725	response to hormone
GO:0014823	response to activity
GO:0032024	positive regulation of insulin secretion
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042182	ketone catabolic process
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0045471	response to ethanol
GO:0046950	cellular ketone body metabolic process
GO:0046952	ketone body catabolic process
GO:0060612	adipose tissue development
GO:0071229	cellular response to acid
GO:0071333	cellular response to glucose stimulus