InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: OXCT1

Summary

InnateDB Gene

IDBG-18717.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

OXCT1

Gene Name

3-oxoacid CoA transferase 1

Synonyms

OXCT; SCOT

Species

Homo sapiens

Ensembl Gene

ENSG00000083720

Encoded Proteins

IDBP-18721

3-oxoacid CoA transferase 1

IDBP-482118

3-oxoacid CoA transferase 1

IDBP-482732

3-oxoacid CoA transferase 1

IDBP-482775

3-oxoacid CoA transferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the 3-oxoacid CoA-transferase gene family. The encoded protein is a homodimeric mitochondrial matrix enzyme that plays a central role in extrahepatic ketone body catabolism by catalyzing the reversible transfer of coenzyme A from succinyl-CoA to acetoacetate. Mutations in this gene are associated with succinyl CoA:3-oxoacid CoA transferase deficiency. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:41730065-41870519

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000196371	ENSP00000196371
ENST00000512084	ENSP00000421143
ENST00000510634	ENSP00000423144
ENST00000509987	ENSP00000425348
ENST00000508557
ENST00000503374
ENST00000513081
ENST00000514723

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	45 [view]
Protein-Protein	45 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008260	3-oxoacid CoA-transferase activity
GO:0008410	CoA-transferase activity
GO:0042803	protein homodimerization activity

Biological Process

GO:0007420	brain development
GO:0007507	heart development
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0009725	response to hormone
GO:0014823	response to activity
GO:0035774	positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042182	ketone catabolic process
GO:0042493	response to drug
GO:0042594	response to starvation
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process
GO:0045471	response to ethanol
GO:0046950	cellular ketone body metabolic process
GO:0046952	ketone body catabolic process
GO:0060612	adipose tissue development

Cellular Component

GO:0005739	mitochondrion
GO:0005759	mitochondrial matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000022186

View Gene Order

ENSBTAG00000033186

Not yet available

Pathways

NETPATH

REACTOME

REACT_59

Utilization of Ketone Bodies pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_1861

Ketone body metabolism pathway

REACT_111217

Metabolism pathway

KEGG

hsa00280

Valine, leucine and isoleucine degradation pathway

hsa00650

Butanoate metabolism pathway

hsa00072

Synthesis and degradation of ketone bodies pathway

INOH

INOH website

Butanoate metabolism pathway

INOH website

Valine Leucine Isoleucine degradation pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.278277

RefSeq

NM_000436

HUGO

OMIM

CCDS

CCDS3937

HPRD

02001

IMGT

EMBL

GenPept

RNA Seq Atlas