Mus musculus Gene: Rictor
Summary
InnateDB Gene IDBG-128168.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rictor
Gene Name RPTOR independent companion of MTOR, complex 2
Synonyms 4921505C17Rik; 6030405M08Rik; AVO3; AW492497; D530039E11Rik;
Species Mus musculus
Ensembl Gene ENSMUSG00000050310
Encoded Proteins
RPTOR independent companion of MTOR, complex 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Rictor reduces Tlr4-mediated inflammation by regulating the cellular localization of Foxo1.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] RICTOR reduces TLR4-mediated inflammation by regulating the cellular localization of FOXO1. (Demonstrated in mice)
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000164327:
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:6708381-6800398
Strand Forward strand
Band A1
Transcripts
ENSMUST00000061656 ENSMUSP00000051809
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 78 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 78 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0043022 ribosome binding
Biological Process
GO:0001938 positive regulation of endothelial cell proliferation
GO:0009790 embryo development
GO:0030838 positive regulation of actin filament polymerization
GO:0031532 actin cytoskeleton reorganization
GO:0031929 TOR signaling
GO:0032008 positive regulation of TOR signaling
GO:0032314 regulation of Rac GTPase activity
GO:0032956 regulation of actin cytoskeleton organization
GO:0042325 regulation of phosphorylation
GO:0045087 innate immune response (InnateDB)
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051896 regulation of protein kinase B signaling
GO:0051897 positive regulation of protein kinase B signaling
Cellular Component
GO:0031932 TORC2 complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Innate Immune System pathway
Signaling by the B Cell Receptor (BCR) pathway
Signaling by ERBB2 pathway
PI3K/AKT activation pathway
CD28 dependent PI3K/Akt signaling pathway
Disease pathway
Signaling by VEGF pathway
Signaling by FGFR in disease pathway
Signaling by ERBB4 pathway
Signaling by SCF-KIT pathway
PIP3 activates AKT signaling pathway
Immune System pathway
Downstream signal transduction pathway
Downstream signaling of activated FGFR pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
PI3K events in ERBB4 signaling pathway
PI-3K cascade pathway
Signaling by EGFR pathway
CD28 co-stimulation pathway
Costimulation by the CD28 family pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
VEGFR2 mediated vascular permeability pathway
VEGFA-VEGFR2 Pathway pathway
Fc epsilon receptor (FCERI) signaling pathway
PI3K/AKT Signaling in Cancer pathway
Signalling by NGF pathway
Adaptive Immune System pathway
Signaling by PDGF pathway
GAB1 signalosome pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K events in ERBB2 signaling pathway
Signal Transduction pathway
Signaling by FGFR pathway
Signaling by EGFR in Cancer pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
DAP12 interactions pathway
DAP12 signaling pathway
KEGG
mTOR signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
Oncostatin_M pathway
REACTOME
Signaling by FGFR in disease pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
PI3K/AKT activation pathway
Downstream signaling of activated FGFR pathway
PI-3K cascade pathway
PI3K events in ERBB2 signaling pathway
DAP12 signaling pathway
Signaling by VEGF pathway
Signaling by EGFR pathway
Role of LAT2/NTAL/LAB on calcium mobilization pathway
Constitutive PI3K/AKT Signaling in Cancer pathway
Innate Immune System pathway
Signaling by ERBB4 pathway
VEGFR2 mediated vascular permeability pathway
Signaling by SCF-KIT pathway
Fc epsilon receptor (FCERI) signaling pathway
Signal Transduction pathway
CD28 co-stimulation pathway
Adaptive Immune System pathway
Immune System pathway
Downstream signal transduction pathway
VEGFA-VEGFR2 Pathway pathway
NGF signalling via TRKA from the plasma membrane pathway
PI3K/AKT Signaling in Cancer pathway
Signaling by FGFR pathway
CD28 dependent PI3K/Akt signaling pathway
PIP3 activates AKT signaling pathway
Signaling by PDGF pathway
Signaling by ERBB2 pathway
Costimulation by the CD28 family pathway
Signaling by the B Cell Receptor (BCR) pathway
GAB1 signalosome pathway
Downstream signaling events of B Cell Receptor (BCR) pathway
Disease pathway
PI3K events in ERBB4 signaling pathway
DAP12 interactions pathway
KEGG
mTOR signaling pathway pathway
INOH
Insulin receptor signaling pathway
PID BIOCARTA
PID NCI
Class I PI3K signaling events mediated by Akt
CXCR4-mediated signaling events
ErbB1 downstream signaling
mTOR signaling pathway
Integrin-linked kinase signaling
CXCR3-mediated signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.275811 Mm.418173
RefSeq NM_030168 XM_006520004
OMIM
CCDS CCDS37032
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas