Mus musculus Gene: Cpt1a
Summary
InnateDB Gene IDBG-128203.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cpt1a
Gene Name carnitine palmitoyltransferase 1a, liver
Synonyms C730027G07; Cpt1; CPTI;
Species Mus musculus
Ensembl Gene ENSMUSG00000024900
Encoded Proteins
carnitine palmitoyltransferase 1a, liver
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110090:
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:3323301-3385732
Strand Forward strand
Band A
Transcripts
ENSMUST00000025835 ENSMUSP00000025835
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 22 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004095 carnitine O-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016746 transferase activity, transferring acyl groups
GO:0042802 identical protein binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006006 glucose metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006641 triglyceride metabolic process
GO:0006810 transport
GO:0009437 carnitine metabolic process
GO:0014070 response to organic cyclic compound
GO:0030855 epithelial cell differentiation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0042493 response to drug
GO:0042755 eating behavior
GO:0046320 regulation of fatty acid oxidation
GO:0050796 regulation of insulin secretion
GO:0051260 protein homooligomerization
GO:0071398 cellular response to fatty acid
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Mus musculus biological processes pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Circadian Clock pathway
Circadian Clock pathway
RORA activates circadian gene expression pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
PPARA activates gene expression pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Rora activates circadian gene expression pathway
KEGG
Fatty acid degradation pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Circadian Clock pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
RORA activates circadian gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Fatty acid degradation pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Reversal of insulin resistance by leptin [Biocarta view]
PID NCI
Cross-References
SwissProt P97742
TrEMBL Q7TQD5
UniProt Splice Variant
Entrez Gene 12894
UniGene Mm.392336
RefSeq NM_013495 XM_006531654 XM_006531655 XM_006531656 XM_006531657 XM_006531658 XM_006531659
OMIM
CCDS CCDS29395
HPRD
IMGT
MGI ID MGI:1098296
MGI Symbol Cpt1a
EMBL AF017175 AK050213 AK077454 AK133472 AK136487 AK149688 BC038395 BC046383 BC054791 CH466612 S82796
GenPept AAB39370 AAC31641 AAH38395 AAH46383 AAH54791 BAC34126 BAC36808 BAE21673 BAE23002 BAE29027 EDL32931 EDL32933
RNA Seq Atlas 12894