InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Cpt1a

Summary

InnateDB Gene

IDBG-128203.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cpt1a

Gene Name

carnitine palmitoyltransferase 1a, liver

Synonyms

C730027G07; Cpt1; CPTI

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024900

Encoded Proteins

IDBP-128205

carnitine palmitoyltransferase 1a, liver

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110090:
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:3323301-3385732

Strand

Forward strand

Band

Transcripts

ENSMUST00000025835

ENSMUSP00000025835

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004095	carnitine O-palmitoyltransferase activity
GO:0005515	protein binding
GO:0016746	transferase activity, transferring acyl groups
GO:0042802	identical protein binding

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006006	glucose metabolic process
GO:0006635	fatty acid beta-oxidation
GO:0006641	triglyceride metabolic process
GO:0006810	transport
GO:0009437	carnitine metabolic process
GO:0014070	response to organic cyclic compound
GO:0030855	epithelial cell differentiation
GO:0032000	positive regulation of fatty acid beta-oxidation
GO:0042493	response to drug
GO:0042755	eating behavior
GO:0046320	regulation of fatty acid oxidation
GO:0050796	regulation of insulin secretion
GO:0051260	protein homooligomerization
GO:0071398	cellular response to fatty acid

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005743	mitochondrial inner membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031307	integral component of mitochondrial outer membrane
GO:0043231	intracellular membrane-bounded organelle