Homo sapiens Gene: CPT1A
Summary
InnateDB Gene IDBG-61582.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPT1A
Gene Name carnitine palmitoyltransferase 1A (liver)
Synonyms CPT1; CPT1-L; L-CPT1;
Species Homo sapiens
Ensembl Gene ENSG00000110090
Encoded Proteins
carnitine palmitoyltransferase 1A (liver)
carnitine palmitoyltransferase 1A (liver)
carnitine palmitoyltransferase 1A (liver)
carnitine palmitoyltransferase 1A (liver)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:68754620-68844410
Strand Reverse strand
Band q13.3
Transcripts
ENST00000376618 ENSP00000365803
ENST00000265641 ENSP00000265641
ENST00000540367 ENSP00000439084
ENST00000539743 ENSP00000446108
ENST00000537756
ENST00000538994 ENSP00000454332
ENST00000569129 ENSP00000455116
ENST00000561996 ENSP00000457663
ENST00000565318 ENSP00000457826
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 31 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004095 carnitine O-palmitoyltransferase activity
GO:0005515 protein binding
GO:0016746 transferase activity, transferring acyl groups
GO:0042802 identical protein binding
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0006006 glucose metabolic process
GO:0006635 fatty acid beta-oxidation
GO:0006641 triglyceride metabolic process
GO:0006853 carnitine shuttle
GO:0008152 metabolic process
GO:0009437 carnitine metabolic process
GO:0014070 response to organic cyclic compound
GO:0030855 epithelial cell differentiation
GO:0032000 positive regulation of fatty acid beta-oxidation
GO:0042493 response to drug
GO:0042755 eating behavior
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0046320 regulation of fatty acid oxidation
GO:0050796 regulation of insulin secretion
GO:0051260 protein homooligomerization
GO:0071398 cellular response to fatty acid
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane
GO:0043231 intracellular membrane-bounded organelle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Circadian Clock pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
RORA activates circadian gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
KEGG
Fatty acid degradation pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Reversal of insulin resistance by leptin [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL H3BMD2
UniProt Splice Variant
Entrez Gene 1374
UniGene Hs.503043 Hs.717370
RefSeq NM_001031847 NM_001876 XM_005273763 XM_005273762
HUGO HGNC:2328
OMIM 600528
CCDS CCDS31624 CCDS8185
HPRD 02755
IMGT
EMBL AP000808 AP003732
GenPept
RNA Seq Atlas 1374