Bos taurus Gene: CPT1A
Summary
InnateDB Gene IDBG-644928.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CPT1A
Gene Name Uncharacterized protein
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000021999
Encoded Proteins
Mitochondrial carnitine palmitoyltransferase 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110090:
The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 29:46822027-46862300
Strand Reverse strand
Band
Transcripts
ENSBTAT00000029336 ENSBTAP00000029336
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004095 carnitine O-palmitoyltransferase activity
GO:0016740 transferase activity
GO:0016746 transferase activity, transferring acyl groups
Biological Process
GO:0001676 long-chain fatty acid metabolic process
GO:0009437 carnitine metabolic process
GO:0030855 epithelial cell differentiation
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Circadian Clock pathway
Metabolism of lipids and lipoproteins pathway
PPARA activates gene expression pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
RORA activates circadian gene expression pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Metabolism pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
Mus musculus biological processes pathway
Fatty acid, triacylglycerol, and ketone body metabolism pathway
Circadian Clock pathway
Circadian Clock pathway
RORA activates circadian gene expression pathway
Metabolism pathway
Metabolism of lipids and lipoproteins pathway
Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway
PPARA activates gene expression pathway
Import of palmitoyl-CoA into the mitochondrial matrix pathway
Rora activates circadian gene expression pathway
KEGG
Fatty acid degradation pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
Fatty acid degradation pathway
PPAR signaling pathway pathway
Adipocytokine signaling pathway pathway
INOH
PID BIOCARTA
Mechanism of gene regulation by peroxisome proliferators via ppara [Biocarta view]
Reversal of insulin resistance by leptin [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Bt.106837
RefSeq XM_001789518 XM_002699420 XM_005197373 XM_005227376
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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