Mus musculus Gene: Skp2
Summary
InnateDB Gene IDBG-128953.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Skp2
Gene Name S-phase kinase-associated protein 2 (p45)
Synonyms 4930500A04Rik; FBXL1; FWD1; p45;
Species Mus musculus
Ensembl Gene ENSMUSG00000054115
Encoded Proteins
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
S-phase kinase-associated protein 2 (p45)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] IFI27 restricts viral infection by recruiting an E3 ligase, SKP2, for ubiquitination and degradation of viral protein.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000145604:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class; in addition to an F-box, this protein contains 10 tandem leucine-rich repeats. This protein is an essential element of the cyclin A-CDK2 S-phase kinase. It specifically recognizes phosphorylated cyclin-dependent kinase inhibitor 1B (CDKN1B, also referred to as p27 or KIP1) predominantly in S phase and interacts with S-phase kinase-associated protein 1 (SKP1 or p19). In addition, this gene is established as a protooncogene causally involved in the pathogenesis of lymphomas. Alternative splicing of this gene generates three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:9111985-9155425
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000096482 ENSMUSP00000094225
ENSMUST00000110585 ENSMUSP00000106215
ENSMUST00000190131 ENSMUSP00000139997
ENSMUST00000191316
ENSMUST00000190406
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 114 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 14 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 114 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000209 protein polyubiquitination
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0048661 positive regulation of smooth muscle cell proliferation
GO:0051726 regulation of cell cycle
GO:0071460 cellular response to cell-matrix adhesion
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0016235 aggresome
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
G1 Phase pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
Cell Cycle pathway
APC/C-mediated degradation of cell cycle proteins pathway
Immune System pathway
Cyclin D associated events in G1 pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
Regulation of mitotic cell cycle pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Adaptive Immune System pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
S Phase pathway
KEGG
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
Notch pathway
REACTOME
G1 Phase pathway
APC/C-mediated degradation of cell cycle proteins pathway
Regulation of mitotic cell cycle pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
Cyclin D associated events in G1 pathway
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
G1/S Transition pathway
Cell Cycle pathway
Adaptive Immune System pathway
Immune System pathway
Antigen processing: Ubiquitination & Proteasome degradation pathway
Cyclin E associated events during G1/S transition pathway
Cell Cycle, Mitotic pathway
Class I MHC mediated antigen processing & presentation pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
KEGG
Cell cycle pathway
Ubiquitin mediated proteolysis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Cell cycle: g1/s check point [Biocarta view]
E2f1 destruction pathway [Biocarta view]
Regulation of p27 phosphorylation during cell cycle progression [Biocarta view]
PID NCI
Regulation of retinoblastoma protein
FoxO family signaling
p53 pathway
C-MYC pathway
FOXM1 transcription factor network
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.35584 Mm.413351
RefSeq NM_001285980 NM_013787 NM_145468
OMIM
CCDS CCDS37037
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas