|Mus musculus Gene: Ddx1|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||DEAD (Asp-Glu-Ala-Asp) box polypeptide 1|
DEAD (Asp-Glu-Ala-Asp) box polypeptide 1
|Useful resources||Stemformatics EHFPI ImmGen|
Ddx1 is a cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. Ddx1 then recruits Ddx21, Dhx36 and Ticam1 to mount type I interferon and cytokine response to poly I:C, influenza A virus, and reovirus.
|InnateDB Annotation from Orthologs|
[Homo sapiens] DDX1 is cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. DDX1 then recruits DDX21, DHX36 and TICAM1 to mount type I interferon and cytokine response to poly I:C, Influenza A virus and reovirus. (Demonstrated in murine model)
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079785:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 12:13219308-13249213|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Not yet available
|UniProt Splice Variant|
|EMBL||AK028341 AK053259 AK153335 AK160982 BC010624|
|GenPept||AAH10624 BAC25893 BAC35325 BAE31914 BAE36130|
|RNA Seq Atlas||104721|