InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: DDX1

Summary

InnateDB Gene

IDBG-637790.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DDX1

Gene Name

ATP-dependent RNA helicase DDX1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000009906

Encoded Proteins

IDBP-689837

ATP-dependent RNA helicase DDX1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 21703541

[Homo sapiens] DDX1 is cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. DDX1 then recruits DDX21, DHX36 and TICAM1 to mount type I interferon and cytokine response to poly I:C, Influenza A virus and reovirus. (Demonstrated in murine model)

PMID 21703541

[Mus musculus] Ddx1 is a cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. Ddx1 then recruits Ddx21, Dhx36 and Ticam1 to mount type I interferon and cytokine response to poly I:C, influenza A virus, and reovirus.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079785:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:82824017-82855964

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000013075

ENSBTAP00000013075

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003712	transcription cofactor activity
GO:0003723	RNA binding
GO:0003725	double-stranded RNA binding
GO:0004386	helicase activity
GO:0004518	nuclease activity
GO:0004527	exonuclease activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008026	ATP-dependent helicase activity
GO:0008143	poly(A) binding
GO:0016787	hydrolase activity
GO:0033677	DNA/RNA helicase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006302	double-strand break repair
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0007275	multicellular organismal development
GO:0009615	response to virus
GO:0032508	DNA duplex unwinding
GO:0043330	response to exogenous dsRNA

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0010494	cytoplasmic stress granule
GO:0016020	membrane
GO:0030529	ribonucleoprotein complex
GO:0071920	cleavage body
GO:0072669	tRNA-splicing ligase complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000079785

View Gene Order

ENSMUSG00000037149

View Gene Order

Cross-References

SwissProt

Q0IIK5

TrEMBL

UniProt Splice Variant

Entrez Gene

510816

UniGene

Bt.1784

RefSeq

NM_001075468 XM_005212963

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC122599

GenPept

AAI22600

RNA Seq Atlas

510816