Bos taurus Gene: DDX1
InnateDB Gene IDBG-637790.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDX1
Gene Name ATP-dependent RNA helicase DDX1
Species Bos taurus
Ensembl Gene ENSBTAG00000009906
Encoded Proteins
ATP-dependent RNA helicase DDX1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
[Homo sapiens] DDX1 is cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. DDX1 then recruits DDX21, DHX36 and TICAM1 to mount type I interferon and cytokine response to poly I:C, Influenza A virus and reovirus. (Demonstrated in murine model)
[Mus musculus] Ddx1 is a cytosolic viral sensor in dendritic cells that binds to dsRNA through its Helicase A domain. Ddx1 then recruits Ddx21, Dhx36 and Ticam1 to mount type I interferon and cytokine response to poly I:C, influenza A virus, and reovirus.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000079785:
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein of unknown function. It shows high transcription levels in 2 retinoblastoma cell lines and in tissues of neuroectodermal origin. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:82824017-82855964
Strand Reverse strand
ENSBTAT00000013075 ENSBTAP00000013075
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003712 transcription cofactor activity
GO:0003723 RNA binding
GO:0003725 double-stranded RNA binding
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0004527 exonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008026 ATP-dependent helicase activity
GO:0008143 poly(A) binding
GO:0016787 hydrolase activity
GO:0033677 DNA/RNA helicase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006200 ATP catabolic process
GO:0006302 double-strand break repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006397 mRNA processing
GO:0007275 multicellular organismal development
GO:0009615 response to virus
GO:0032508 DNA duplex unwinding
GO:0043330 response to exogenous dsRNA
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010494 cytoplasmic stress granule
GO:0016020 membrane
GO:0030529 ribonucleoprotein complex
GO:0071920 cleavage body
GO:0072669 tRNA-splicing ligase complex
Homo sapiens
Mus musculus
Gene ID
Gene Order
SwissProt Q0IIK5
UniProt Splice Variant
Entrez Gene 510816
UniGene Bt.1784
RefSeq NM_001075468 XM_005212963
EMBL BC122599
GenPept AAI22600
RNA Seq Atlas 510816