Mus musculus Gene: Pfkp
Summary
InnateDB Gene IDBG-128989.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Pfkp
Gene Name phosphofructokinase, platelet
Synonyms 1200015H23Rik; 9330125N24Rik; ATP-PFK; PFK-C; PFK-P;
Species Mus musculus
Ensembl Gene ENSMUSG00000021196
Encoded Proteins
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
phosphofructokinase, platelet
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067057:
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:6579768-6648777
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000021614 ENSMUSP00000021614
ENSMUST00000131648
ENSMUST00000138703 ENSMUSP00000117030
ENSMUST00000142972 ENSMUSP00000114439
ENSMUST00000154100 ENSMUSP00000116523
ENSMUST00000133041 ENSMUSP00000123662
ENSMUST00000142372
ENSMUST00000151894
ENSMUST00000144053
ENSMUST00000148999
ENSMUST00000135761
ENSMUST00000137327
ENSMUST00000136585 ENSMUSP00000115313
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding
GO:0032403 protein complex binding
GO:0046872 metal ion binding
Biological Process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Disease pathway
Glycolysis pathway
Glucose metabolism pathway
Metabolism pathway
Glycogen storage diseases pathway
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Galactose metabolism pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Myoclonic epilepsy of Lafora pathway
Metabolism of carbohydrates pathway
Glycolysis pathway
Metabolism pathway
Disease pathway
Glucose metabolism pathway
Glycogen storage diseases pathway
KEGG
Glycolysis / Gluconeogenesis pathway
Pentose phosphate pathway pathway
Fructose and mannose metabolism pathway
Galactose metabolism pathway
INOH
Pentose phosphate cycle pathway
Glycolysis Gluconeogenesis pathway
PID BIOCARTA
Phosphoinositides and their downstream targets [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 56421
UniGene Mm.406927
RefSeq NM_001291071 NM_019703 XM_006516486 XM_006516489
OMIM
CCDS CCDS70427 CCDS26230
HPRD
IMGT
MGI ID MGI:1891833
MGI Symbol Pfkp
EMBL
GenPept
RNA Seq Atlas 56421