InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PFKP

Summary

InnateDB Gene

IDBG-639573.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKP

Gene Name

6-phosphofructokinase type C

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000002683

Encoded Proteins

IDBP-691754

phosphofructokinase, platelet

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000067057:
The PFKP gene encodes the platelet isoform of phosphofructokinase (PFK) (ATP:D-fructose-6-phosphate-1-phosphotransferase, EC 2.7.1.11). PFK catalyzes the irreversible conversion of fructose-6-phosphate to fructose-1,6-bisphosphate and is a key regulatory enzyme in glycolysis. The PFKP gene, which maps to chromosome 10p, is also expressed in fibroblasts. See also the muscle (PFKM; MIM 610681) and liver (PFKL; MIM 171860) isoforms of phosphofructokinase, which map to chromosomes 12q13 and 21q22, respectively. Vora (1981) [PubMed 6451249] determined that full tetrameric phophofructokinase enzyme expressed in platelets can be composed of subunits P4, P3L, and P2L2.[supplied by OMIM, Mar 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:45500599-45553520

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000003472

ENSBTAP00000003472

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.

Predicted by orthology
Total	33 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003872	6-phosphofructokinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0032403	protein complex binding

Biological Process

GO:0006002	fructose 6-phosphate metabolic process
GO:0006096	glycolytic process
GO:0016310	phosphorylation
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005945	6-phosphofructokinase complex
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome