Version 5.4
Mus musculus Gene: Zmynd11
Summary
InnateDB Gene IDBG-129466.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Zmynd11
Gene Name zinc finger, MYND domain containing 11
Synonyms 2210402G22Rik; BS69
Species Mus musculus
Ensembl Gene ENSMUSG00000021156
Encoded Proteins
IDBP-129468
zinc finger, MYND domain containing 11
IDBP-259830
zinc finger, MYND domain containing 11
IDBP-259832
zinc finger, MYND domain containing 11
IDBP-259834
zinc finger, MYND domain containing 11
IDBP-259836
zinc finger, MYND domain containing 11
IDBP-259838
zinc finger, MYND domain containing 11
IDBP-259840
zinc finger, MYND domain containing 11
IDBP-533607
zinc finger, MYND domain containing 11
IDBP-532301
zinc finger, MYND domain containing 11
IDBP-541937
zinc finger, MYND domain containing 11
IDBP-531843
zinc finger, MYND domain containing 11
IDBP-535169
zinc finger, MYND domain containing 11
IDBP-539242
zinc finger, MYND domain containing 11
IDBP-538869
zinc finger, MYND domain containing 11
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 19795416
[Homo sapiens] Nuclear ZMYND11 is recruited by oligomerized, cytoplasmic TICAM1 to enhance NF-kappaB activation and type-I-interferon induction. ZMYND11 harbours dual modes of cytoplasmic NF-kappaB regulation, positively in the TICAM1 pathway and negatively in the PDLIM7 (LMP1) pathway.
PMID 20138174
[Homo sapiens] ZMYND11 cooperates with TRAF3 in the regulation of Epstein-Barr virus-derived LMP1/CTAR1-induced NF-kappaB activation.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000015171:
The protein encoded by this gene was first identified by its ability to bind the adenovirus E1A protein. The protein localizes to the nucleus. It functions as a transcriptional repressor, and expression of E1A inhibits this repression. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:9684836-9765321
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000062658 ENSMUSP00000059767
ENSMUST00000110638 ENSMUSP00000106268
ENSMUST00000110637 ENSMUSP00000106267
ENSMUST00000110636 ENSMUSP00000106266
ENSMUST00000110635 ENSMUSP00000106265
ENSMUST00000110634 ENSMUSP00000106264
ENSMUST00000110633 ENSMUSP00000106263
ENSMUST00000137932
ENSMUST00000137813
ENSMUST00000138039
ENSMUST00000130151 ENSMUSP00000118964
ENSMUST00000154994 ENSMUSP00000116635
ENSMUST00000152725 ENSMUSP00000118002
ENSMUST00000128658 ENSMUSP00000121574
ENSMUST00000157035
ENSMUST00000140180
ENSMUST00000146059 ENSMUSP00000122133
ENSMUST00000144642 ENSMUSP00000117375
ENSMUST00000146039 ENSMUSP00000116299
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 28 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035064 methylated histone binding
GO:0042393 histone binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0016568 chromatin modification
GO:0034243 regulation of transcription elongation from RNA polymerase II promoter
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0046329 negative regulation of JNK cascade
GO:2001237 negative regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000015171
View Gene Order
ENSBTAG00000002578
Not yet available
Cross-References
SwissProt
TrEMBL D3YY86 D3Z662
UniProt Splice Variant
Entrez Gene 66505
UniGene Mm.397307 Mm.473000 Mm.473030 Mm.488717
RefSeq NM_001199141 NM_144516 XM_006516503 XM_006516504 XM_006516505 XM_006516506 XM_006516507
OMIM
CCDS CCDS36590 CCDS56870
HPRD
IMGT
MGI ID MGI:1913755
MGI Symbol Zmynd11
EMBL AC146596 AC153144
GenPept
RNA Seq Atlas 66505

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca