Version 5.4
Mus musculus Gene: C1qtnf3
Summary
InnateDB Gene IDBG-129495.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1qtnf3
Gene Name C1q and tumor necrosis factor related protein 3
Synonyms 2310005P21Rik; Corcs; Cors; CORS-26; CORS26; CTRP3
Species Mus musculus
Ensembl Gene ENSMUSG00000058914
Encoded Proteins
IDBP-129497
C1q and tumor necrosis factor related protein 3
IDBP-260111
C1q and tumor necrosis factor related protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 20739398
[Homo sapiens] C1q/TNF-related protein-3 (AMACR;C1QTNF3), a protein secreted by adipocytes (adipokine), inhibits three basic and common pro-inflammatory pathways involved in obesity and type 2 diabetes mellitus (adipo-inflammation) by acting as an endogenous LPS antagonist of the adipose tissue.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000082196:
Gene Information
Type Protein coding
Genomic Location Chromosome 15:10952332-10980150
Strand Forward strand
Band A1
Transcripts
ENSMUST00000022853 ENSMUSP00000022853
ENSMUST00000110523 ENSMUSP00000106152
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0042593 glucose homeostasis
GO:0045721 negative regulation of gluconeogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0051259 protein oligomerization
GO:0051897 positive regulation of protein kinase B signaling
GO:0070165 positive regulation of adiponectin secretion
GO:0070374 positive regulation of ERK1 and ERK2 cascade
Cellular Component
GO:0005576 extracellular region
GO:0005581 collagen trimer
GO:0005615 extracellular space
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000082196
View Gene Order
ENSBTAG00000017071
Not yet available
Cross-References
SwissProt Q9ES30
TrEMBL D3YZ61 Q4ZJN6
UniProt Splice Variant
Entrez Gene 81799
UniGene Mm.280158
RefSeq NM_001204134 NM_030888
OMIM
CCDS CCDS27380 CCDS56977
HPRD
IMGT
MGI ID MGI:1932136
MGI Symbol C1qtnf3
EMBL AC102219 AF246265 AK029352 AK075867 AK081704 BC055047 BC055859 CH466581 DQ002396
GenPept AAG33704 AAH55047 AAH55859 AAY21928 BAC26412 BAC36016 BAC38301 EDL03289
RNA Seq Atlas 81799

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca