Version 5.4
Homo sapiens Gene: C1QTNF3
Summary
InnateDB Gene IDBG-15015.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1QTNF3
Gene Name C1q and tumor necrosis factor related protein 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000082196
Encoded Proteins
IDBP-15019
C1q and tumor necrosis factor related protein 3
IDBP-15029
C1q and tumor necrosis factor related protein 3
IDBP-15031
C1q and tumor necrosis factor related protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 20739398
C1q/TNF-related protein-3 (AMACR;C1QTNF3), a protein secreted by adipocytes (adipokine), inhibits three basic and common pro-inflammatory pathways involved in obesity and type 2 diabetes mellitus (adipo-inflammation) by acting as an endogenous LPS antagonist of the adipose tissue.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 5:34019448-34043832
Strand Reverse strand
Band p13.2
Transcripts
ENST00000382079 ENSP00000371511
ENST00000231338 ENSP00000231338
ENST00000382065 ENSP00000371497
ENST00000508398
ENST00000513471
ENST00000513065
ENST00000508434
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0010629 negative regulation of gene expression
GO:0035356 cellular triglyceride homeostasis
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0045087 innate immune response (InnateDB)
GO:0045444 fat cell differentiation
GO:0045721 negative regulation of gluconeogenesis
GO:0050715 positive regulation of cytokine secretion
GO:0050728 negative regulation of inflammatory response
GO:0070165 positive regulation of adiponectin secretion
GO:0070206 protein trimerization
GO:0071638 negative regulation of monocyte chemotactic protein-1 production
GO:1900165 negative regulation of interleukin-6 secretion
Cellular Component
GO:0005581 collagen trimer
GO:0005615 extracellular space
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058914
View Gene Order
ENSBTAG00000017071
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.603217 Hs.605266
RefSeq NM_030945 NM_181435
HUGO
OMIM
CCDS CCDS34141 CCDS3904
HPRD 12716
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca