InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Timm17b

Summary

InnateDB Gene

IDBG-129727.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Timm17b

Gene Name

translocase of inner mitochondrial membrane 17b

Synonyms

17kDa; mTim17b; Sfc3

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031158

Encoded Proteins

IDBP-129729

translocase of inner mitochondrial membrane 17b

IDBP-537112

translocase of inner mitochondrial membrane 17b

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000126768:
This gene encodes a protein that is part of the mitochondrial transport TIMM23 complex. TIM translocase complexes facilitate the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. Two alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009]
This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:7899357-7908351

Strand

Forward strand

Band

A1.1

Transcripts

ENSMUST00000033498	ENSMUSP00000033498
ENSMUST00000146406	ENSMUSP00000117340
ENSMUST00000150541

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	9 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity

Biological Process

GO:0006886	intracellular protein transport
GO:0071806	protein transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005744	mitochondrial inner membrane presequence translocase complex
GO:0015630	microtubule cytoskeleton
GO:0016021	integral component of membrane
GO:0031305	integral component of mitochondrial inner membrane

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000126768

View Gene Order

ENSBTAG00000018496

Not yet available

Pathways

NETPATH

REACTOME

REACT_247926

Metabolism of proteins pathway

REACT_199101

Mitochondrial protein import pathway

KEGG

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_17015

Metabolism of proteins pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9Z0V7

TrEMBL

Q3UAF0 Q545H3

UniProt Splice Variant

Entrez Gene

21855

UniGene

Mm.27393

RefSeq

NM_011591

OMIM

CCDS

CCDS29978

HPRD

IMGT

MGI ID

MGI:1343176

MGI Symbol

Timm17b

EMBL

AF106621 AK003204 AK009164 AK011830 AK049584 AK151396 AK153097 BC008275

GenPept

AAD19595 AAH08275 BAB22640 BAB26115 BAB27865 BAC33827 BAE30364 BAE31718

RNA Seq Atlas

21855