Version 5.4
Mus musculus Gene: Lypla1
Summary
InnateDB Gene IDBG-131645.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Lypla1
Gene Name lysophospholipase 1
Synonyms Pla1a
Species Mus musculus
Ensembl Gene ENSMUSG00000025903
Encoded Proteins
IDBP-131647
lysophospholipase 1
IDBP-249427
lysophospholipase 1
IDBP-713618
IDBP-715394
IDBP-713865
IDBP-537863
lysophospholipase 1
IDBP-713783
IDBP-541622
lysophospholipase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120992:
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 1:4807788-4886770
Strand Forward strand
Band A1
Transcripts
ENSMUST00000027036 ENSMUSP00000027036
ENSMUST00000115529 ENSMUSP00000111191
ENSMUST00000119612 ENSMUSP00000137647
ENSMUST00000134384 ENSMUSP00000137104
ENSMUST00000155020 ENSMUSP00000136108
ENSMUST00000137887 ENSMUSP00000119456
ENSMUST00000150971 ENSMUSP00000137248
ENSMUST00000131119 ENSMUSP00000118453
ENSMUST00000141278
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity
Biological Process
GO:0002084 protein depalmitoylation
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
GO:0042997 negative regulation of Golgi to plasma membrane protein transport
Cellular Component
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000120992
View Gene Order
ENSBTAG00000004243
Not yet available
Pathways
NETPATH
REACTOME
REACT_204801
eNOS activation and regulation pathway
REACT_221264
eNOS activation pathway
REACT_188937
Metabolism pathway
REACT_208364
Metabolism of nitric oxide pathway
KEGG
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12477
eNOS activation pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
REACT_217977
eNOS activation pathway
REACT_226352
eNOS activation and regulation pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_219139
Metabolism pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.299955 Mm.396313
RefSeq NM_008866 XM_006495472
OMIM
CCDS CCDS14806
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca