Version 5.4
Bos taurus Gene: LYPLA1
Summary
InnateDB Gene IDBG-644411.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol LYPLA1
Gene Name Acyl-protein thioesterase 1
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000004243
Encoded Proteins
IDBP-697045
Acyl-protein thioesterase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000120992:
Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene hydrolyzes lysophosphatidylcholine in both monomeric and micellar forms. The use of alternate polyadenylation sites has been found for this gene. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:23651477-23668800
Strand Reverse strand
Band
Transcripts
ENSBTAT00000005558 ENSBTAP00000005558
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008474 palmitoyl-(protein) hydrolase activity
GO:0016787 hydrolase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0008152 metabolic process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
ENSG00000120992
View Gene Order
ENSMUSG00000025903
View Gene Order
Pathways
NETPATH
REACTOME
REACT_217977
eNOS activation pathway
REACT_226352
eNOS activation and regulation pathway
REACT_220341
Metabolism of nitric oxide pathway
REACT_219139
Metabolism pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_12477
eNOS activation pathway
REACT_12389
eNOS activation and regulation pathway
REACT_12508
Metabolism of nitric oxide pathway
REACT_111217
Metabolism pathway
REACT_204801
eNOS activation and regulation pathway
REACT_221264
eNOS activation pathway
REACT_188937
Metabolism pathway
REACT_208364
Metabolism of nitric oxide pathway
KEGG
hsa00564
Glycerophospholipid metabolism pathway
mmu00564
Glycerophospholipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q3MHR0
TrEMBL
UniProt Splice Variant
Entrez Gene 539992
UniGene Bt.101836 Bt.13850
RefSeq NM_001034688 XM_005215418 XM_005215420
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105143
GenPept AAI05144
RNA Seq Atlas 539992

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca