Mus musculus Gene: Efnb2
Summary
InnateDB Gene IDBG-131775.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Efnb2
Gene Name ephrin B2
Synonyms ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5; NLERK-1;
Species Mus musculus
Ensembl Gene ENSMUSG00000001300
Encoded Proteins
ephrin B2
ephrin B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125266:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:8617434-8660773
Strand Reverse strand
Band A1.1
Transcripts
ENSMUST00000001319 ENSMUSP00000001319
ENSMUST00000152698 ENSMUSP00000116027
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0001945 lymph vessel development
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0007155 cell adhesion
GO:0007411 axon guidance
GO:0009887 organ morphogenesis
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016477 cell migration
GO:0048013 ephrin receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050920 regulation of chemotaxis
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Developmental Biology pathway
Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
EGFR1 pathway
REACTOME
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Ephrin signaling pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
EPHB forward signaling
Ephrin B reverse signaling
EphrinB-EPHB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 13642
UniGene Mm.209813 Mm.400569 Mm.402920 Mm.414965
RefSeq NM_010111
OMIM
CCDS CCDS22090
HPRD
IMGT
MGI ID MGI:105097
MGI Symbol Efnb2
EMBL
GenPept
RNA Seq Atlas 13642