InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Efnb2

Summary

InnateDB Gene

IDBG-131775.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Efnb2

Gene Name

ephrin B2

Synonyms

ELF-2; Epl5; Eplg5; Htk-L; LERK-5; Lerk5; NLERK-1

Species

Mus musculus

Ensembl Gene

ENSMUSG00000001300

Encoded Proteins

IDBP-131777

ephrin B2

IDBP-536255

ephrin B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000125266:
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 8:8617434-8660773

Strand

Reverse strand

Band

A1.1

Transcripts

ENSMUST00000001319	ENSMUSP00000001319
ENSMUST00000152698	ENSMUSP00000116027

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001945	lymph vessel development
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007411	axon guidance
GO:0009887	organ morphogenesis
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016477	cell migration
GO:0048013	ephrin receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0050920	regulation of chemotaxis
GO:2000727	positive regulation of cardiac muscle cell differentiation