InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EFNB2

Summary

InnateDB Gene

IDBG-49553.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EFNB2

Gene Name

ephrin-B2

Synonyms

EPLG5; Htk-L; HTKL; LERK5

Species

Homo sapiens

Ensembl Gene

ENSG00000125266

Encoded Proteins

IDBP-49555

ephrin-B2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 13:106489731-106535114

Strand

Reverse strand

Band

q33.3

Transcripts

ENST00000245323

ENSP00000245323

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0046875	ephrin receptor binding

Biological Process

GO:0001945	lymph vessel development
GO:0002042	cell migration involved in sprouting angiogenesis
GO:0007155	cell adhesion
GO:0007267	cell-cell signaling
GO:0007411	axon guidance
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0010839	negative regulation of keratinocyte proliferation
GO:0016032	viral process
GO:0048013	ephrin receptor signaling pathway
GO:0048514	blood vessel morphogenesis
GO:0050920	regulation of chemotaxis
GO:2000727	positive regulation of cardiac muscle cell differentiation