Homo sapiens Gene: EFNB2
Summary
InnateDB Gene IDBG-49553.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EFNB2
Gene Name ephrin-B2
Synonyms EPLG5; Htk-L; HTKL; LERK5;
Species Homo sapiens
Ensembl Gene ENSG00000125266
Encoded Proteins
ephrin-B2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:106489731-106535114
Strand Reverse strand
Band q33.3
Transcripts
ENST00000245323 ENSP00000245323
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0001945 lymph vessel development
GO:0002042 cell migration involved in sprouting angiogenesis
GO:0007155 cell adhesion
GO:0007267 cell-cell signaling
GO:0007411 axon guidance
GO:0009653 anatomical structure morphogenesis
GO:0009887 organ morphogenesis
GO:0010839 negative regulation of keratinocyte proliferation
GO:0016032 viral process
GO:0048013 ephrin receptor signaling pathway
GO:0048514 blood vessel morphogenesis
GO:0050920 regulation of chemotaxis
GO:2000727 positive regulation of cardiac muscle cell differentiation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
Developmental Biology pathway
EPHB-mediated forward signaling pathway
Axon guidance pathway
Ephrin signaling pathway
EPH-ephrin mediated repulsion of cells pathway
EPH-Ephrin signaling pathway
KEGG
Axon guidance pathway
INOH
PID BIOCARTA
PID NCI
EPHB forward signaling
Ephrin B reverse signaling
EphrinB-EPHB pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.149239 Hs.594558 Hs.612691 Hs.716220
RefSeq NM_004093
HUGO
OMIM
CCDS CCDS9507
HPRD 02754
IMGT
EMBL
GenPept
RNA Seq Atlas