InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Birc3

Summary

InnateDB Gene

IDBG-133177.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Birc3

Gene Name

baculoviral IAP repeat-containing 3

Synonyms

Api1; Api2; AW107670; Birc2; cIAP-1; cIAP-2; cIAP1; cIAP2; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; MIHC; RNF49

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032000

Encoded Proteins

IDBP-133179

baculoviral IAP repeat-containing 3

IDBP-249118

baculoviral IAP repeat-containing 3

IDBP-249120

baculoviral IAP repeat-containing 3

IDBP-540122

baculoviral IAP repeat-containing 3

IDBP-534435

baculoviral IAP repeat-containing 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21447281

Birc3 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.

InnateDB Annotation from Orthologs

Summary

PMID 18697935

[Homo sapiens] BIRC3 is required for proper RIPK1 polyubiquitination and NF-kappaB activation upon TNF (TNF-alpha) treatment and regulates TNF-mediated NF-kappaB activation by binding to TNFRSF1A (TNFR1).

PMID 19464198

[Homo sapiens] BIRC3 and BIRC2 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023445:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:7848699-7873186

Strand

Reverse strand

Band

Transcripts

ENSMUST00000013949	ENSMUSP00000013949
ENSMUST00000115673	ENSMUSP00000111337
ENSMUST00000115672	ENSMUSP00000111336
ENSMUST00000161642	ENSMUSP00000125512
ENSMUST00000159323	ENSMUSP00000125652
ENSMUST00000161099
ENSMUST00000159672

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.

Experimentally validated
Total	38 [view]
Protein-Protein	37 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	83 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0006915	apoptotic process
GO:0007283	spermatogenesis
GO:0016567	protein ubiquitination
GO:0031398	positive regulation of protein ubiquitination
GO:0042326	negative regulation of phosphorylation
GO:0042981	regulation of apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0051291	protein heterooligomerization
GO:0060544	regulation of necroptotic process
GO:0060546	negative regulation of necroptotic process
GO:0070266	necroptotic process
GO:2000378	negative regulation of reactive oxygen species metabolic process