Mus musculus Gene: Birc3
Summary
InnateDB Gene IDBG-133177.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Birc3
Gene Name baculoviral IAP repeat-containing 3
Synonyms Api1; Api2; AW107670; Birc2; cIAP-1; cIAP-2; cIAP1; cIAP2; HIAP2; IAP1; IAP2; MIAP1; MIAP2; MIHB; MIHC; RNF49;
Species Mus musculus
Ensembl Gene ENSMUSG00000032000
Encoded Proteins
baculoviral IAP repeat-containing 3
baculoviral IAP repeat-containing 3
baculoviral IAP repeat-containing 3
baculoviral IAP repeat-containing 3
baculoviral IAP repeat-containing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Birc3 facilitates ubiquitin-dependent signalling activated by pattern recognition receptors, such as TLR and NOD, to mediate the activation of NFKB transcription.
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] BIRC3 is required for proper RIPK1 polyubiquitination and NF-kappaB activation upon TNF (TNF-alpha) treatment and regulates TNF-mediated NF-kappaB activation by binding to TNFRSF1A (TNFR1).
[Homo sapiens] BIRC3 and BIRC2 are required for innate immunity signalling by the pattern recognition receptors NOD1 and NOD2.
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000023445:
This gene encodes a member of the IAP family of proteins that inhibit apoptosis by binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2, probably by interfering with activation of ICE-like proteases. The encoded protein inhibits apoptosis induced by serum deprivation but does not affect apoptosis resulting from exposure to menadione, a potent inducer of free radicals. It contains 3 baculovirus IAP repeats and a ring finger domain. Transcript variants encoding the same isoform have been identified. [provided by RefSeq, Aug 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:7848699-7873186
Strand Reverse strand
Band A1
Transcripts
ENSMUST00000013949 ENSMUSP00000013949
ENSMUST00000115673 ENSMUSP00000111337
ENSMUST00000115672 ENSMUSP00000111336
ENSMUST00000161642 ENSMUSP00000125512
ENSMUST00000159323 ENSMUSP00000125652
ENSMUST00000161099
ENSMUST00000159672
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 38 experimentally validated interaction(s) in this database.
They are also associated with 83 interaction(s) predicted by orthology.
Experimentally validated
Total 38 [view]
Protein-Protein 37 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 83 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
Biological Process
GO:0006915 apoptotic process
GO:0007283 spermatogenesis
GO:0016567 protein ubiquitination
GO:0031398 positive regulation of protein ubiquitination
GO:0042326 negative regulation of phosphorylation
GO:0042981 regulation of apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0051291 protein heterooligomerization
GO:0060544 regulation of necroptotic process
GO:0060546 negative regulation of necroptotic process
GO:0070266 necroptotic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0043234 protein complex
GO:0045121 membrane raft
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Toll Like Receptor 3 (TLR3) Cascade pathway
Innate Immune System pathway
Immune System pathway
Toll-Like Receptors Cascades pathway
Activated TLR4 signalling pathway
IKK complex recruitment mediated by RIP1 pathway
MyD88-independent cascade pathway
TRIF-mediated TLR3/TLR4 signaling pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
Ubiquitin mediated proteolysis pathway
Apoptosis pathway
Focal adhesion pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
TNFalpha pathway
REACTOME
Innate Immune System pathway
IKK complex recruitment mediated by RIP1 pathway
Toll Like Receptor 3 (TLR3) Cascade pathway
Toll-Like Receptors Cascades pathway
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
NOD1/2 Signaling Pathway pathway
Immune System pathway
MyD88-independent cascade pathway
Toll Like Receptor 4 (TLR4) Cascade pathway
Activated TLR4 signalling pathway
TRIF-mediated TLR3/TLR4 signaling pathway
KEGG
Ubiquitin mediated proteolysis pathway
Apoptosis pathway
Focal adhesion pathway
NOD-like receptor signaling pathway pathway
Toxoplasmosis pathway
Pathways in cancer pathway
Small cell lung cancer pathway
INOH
PID BIOCARTA
Role of mitochondria in apoptotic signaling [Biocarta view]
Keratinocyte differentiation [Biocarta view]
Tnfr1 signaling pathway [Biocarta view]
Hiv-1 nef: negative effector of fas and tnf [Biocarta view]
Sodd/tnfr1 signaling pathway [Biocarta view]
Ceramide signaling pathway [Biocarta view]
Caspase cascade in apoptosis [Biocarta view]
PID NCI
CD40/CD40L signaling
Ceramide signaling pathway
Caspase Cascade in Apoptosis
TNF receptor signaling pathway
C-MYB transcription factor network
HIV-1 Nef: Negative effector of Fas and TNF-alpha
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_007464 XM_006509828 XM_006509829 XM_006509830 XM_006509831 XM_006509832
OMIM
CCDS CCDS22812
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas