InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Top2b

Summary

InnateDB Gene

IDBG-133323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Top2b

Gene Name

topoisomerase (DNA) II beta

Synonyms

D230016L12Rik; Top-2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000017485

Encoded Proteins

IDBP-133325

topoisomerase (DNA) II beta

IDBP-540389

topoisomerase (DNA) II beta

IDBP-536965

topoisomerase (DNA) II beta

IDBP-538948

topoisomerase (DNA) II beta

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000077097:
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:16365179-16430787

Strand

Forward strand

Band

Transcripts

ENSMUST00000017629	ENSMUSP00000017629
ENSMUST00000159987
ENSMUST00000160501	ENSMUSP00000124889
ENSMUST00000159302	ENSMUSP00000123789
ENSMUST00000161693	ENSMUSP00000123992
ENSMUST00000163032

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	17 [view]
Protein-Protein	16 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003918	DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008022	protein C-terminus binding
GO:0008301	DNA binding, bending
GO:0019899	enzyme binding
GO:0042826	histone deacetylase binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000712	resolution of meiotic recombination intermediates
GO:0000819	sister chromatid segregation
GO:0001764	neuron migration
GO:0006200	ATP catabolic process
GO:0006265	DNA topological change
GO:0006268	DNA unwinding involved in DNA replication
GO:0006312	mitotic recombination
GO:0007409	axonogenesis
GO:0030900	forebrain development
GO:0044774	mitotic DNA integrity checkpoint

Cellular Component

GO:0000792	heterochromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0009330	DNA topoisomerase complex (ATP-hydrolyzing)
GO:0071778	WINAC complex

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000077097

View Gene Order

ENSBTAG00000004593

Not yet available

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Mm.130362 Mm.404738

RefSeq

NM_009409

OMIM

CCDS

CCDS26833

HPRD

IMGT

MGI ID

MGI Symbol

EMBL

GenPept

RNA Seq Atlas