Homo sapiens Gene: TOP2B
Summary
InnateDB Gene IDBG-22611.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TOP2B
Gene Name topoisomerase (DNA) II beta 180kDa
Synonyms top2beta; TOPIIB;
Species Homo sapiens
Ensembl Gene ENSG00000077097
Encoded Proteins
topoisomerase (DNA) II beta 180kDa
topoisomerase (DNA) II beta 180kDa
topoisomerase (DNA) II beta 180kDa
topoisomerase (DNA) II beta 180kDa
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing of this gene results in two transcript variants; however, the second variant has not yet been fully described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:25597905-25664907
Strand Reverse strand
Band p24.2
Transcripts
ENST00000264331 ENSP00000264331
ENST00000435706 ENSP00000396704
ENST00000413971 ENSP00000388216
ENST00000424225 ENSP00000391112
ENST00000475717
ENST00000470132
ENST00000491510
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 62 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 62 [view]
Protein-Protein 59 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity
GO:0005080 protein kinase C binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008301 DNA binding, bending
GO:0019899 enzyme binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0000712 resolution of meiotic recombination intermediates
GO:0000819 sister chromatid segregation
GO:0001764 neuron migration
GO:0006200 ATP catabolic process
GO:0006265 DNA topological change
GO:0006268 DNA unwinding involved in DNA replication
GO:0006312 mitotic recombination
GO:0007409 axonogenesis
GO:0030900 forebrain development
GO:0044774 mitotic DNA integrity checkpoint
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
Control of gene expression by vitamin d receptor [Biocarta view]
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.475733 Hs.614320
RefSeq NM_001068 XM_005265427
HUGO
OMIM
CCDS CCDS46776
HPRD 00537
IMGT
EMBL
GenPept
RNA Seq Atlas