Version 5.4
Homo sapiens Gene: ADRA1A
Summary
InnateDB Gene IDBG-13362.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADRA1A
Gene Name adrenoceptor alpha 1A
Synonyms ADRA1C; ADRA1L1; ALPHA1AAR
Species Homo sapiens
Ensembl Gene ENSG00000120907
Encoded Proteins
IDBP-13364
adrenergic, alpha-1A-, receptor
IDBP-13374
adrenergic, alpha-1A-, receptor
IDBP-13378
adrenergic, alpha-1A-, receptor
IDBP-13382
adrenergic, alpha-1A-, receptor
IDBP-13384
adrenergic, alpha-1A-, receptor
IDBP-13386
adrenergic, alpha-1A-, receptor
IDBP-484953
adrenergic, alpha-1A-, receptor
IDBP-482686
adrenergic, alpha-1A-, receptor
IDBP-484405
adrenergic, alpha-1A-, receptor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1A-adrenergic receptor. Alternative splicing of this gene generates four transcript variants, which encode four different isoforms with distinct C-termini but having similar ligand binding properties. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:26748150-26867273
Strand Reverse strand
Band p21.2
Transcripts
ENST00000380586 ENSP00000369960
ENST00000380582 ENSP00000369956
ENST00000354550 ENSP00000346557
ENST00000276393 ENSP00000276393
ENST00000380573 ENSP00000369947
ENST00000380572 ENSP00000369946
ENST00000519096 ENSP00000431073
ENST00000521711 ENSP00000430414
ENST00000519229 ENSP00000430793
ENST00000518621
ENST00000518810
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004930 G-protein coupled receptor activity
GO:0004937 alpha1-adrenergic receptor activity
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001985 negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure
GO:0001994 norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001996 positive regulation of heart rate by epinephrine-norepinephrine
GO:0001997 positive regulation of the force of heart contraction by epinephrine-norepinephrine
GO:0003084 positive regulation of systemic arterial blood pressure
GO:0006915 apoptotic process
GO:0006939 smooth muscle contraction
GO:0007165 signal transduction
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007267 cell-cell signaling
GO:0007512 adult heart development
GO:0007568 aging
GO:0008285 negative regulation of cell proliferation
GO:0009725 response to hormone
GO:0010460 positive regulation of heart rate
GO:0016049 cell growth
GO:0019229 regulation of vasoconstriction
GO:0032229 negative regulation of synaptic transmission, GABAergic
GO:0032230 positive regulation of synaptic transmission, GABAergic
GO:0035024 negative regulation of Rho protein signal transduction
GO:0035265 organ growth
GO:0035556 intracellular signal transduction
GO:0042493 response to drug
GO:0043410 positive regulation of MAPK cascade
GO:0045760 positive regulation of action potential
GO:0045907 positive regulation of vasoconstriction
GO:0045987 positive regulation of smooth muscle contraction
GO:0055117 regulation of cardiac muscle contraction
GO:0060073 micturition
GO:0060402 calcium ion transport into cytosol
GO:0060452 positive regulation of cardiac muscle contraction
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071875 adrenergic receptor signaling pathway
GO:0090037 positive regulation of protein kinase C signaling
GO:0097195 pilomotor reflex
Cellular Component
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030018 Z disc
GO:0030315 T-tubule
GO:0031965 nuclear membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000045875
View Gene Order
ENSBTAG00000031632
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_16927
Adrenoceptors pathway
REACT_16983
Amine ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04020
Calcium signaling pathway pathway
hsa04270
Vascular smooth muscle contraction pathway
hsa04970
Salivary secretion pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.683494
RefSeq NM_000680 NM_033302 NM_033303 NM_033304 XM_005273414 XM_006716292 XM_006716293
HUGO
OMIM
CCDS CCDS34869 CCDS6052 CCDS6053 CCDS6054
HPRD 00081
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca