InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: KDM6A

Summary

InnateDB Gene

IDBG-637770.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

KDM6A

Gene Name

Uncharacterized protein

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000003740

Encoded Proteins

IDBP-689890

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000147050:
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. [provided by RefSeq, Nov 2009]
This gene is located on the X chromosome and is the corresponding locus to a Y-linked gene which encodes a tetratricopeptide repeat (TPR) protein. The encoded protein of this gene contains a JmjC-domain and catalyzes the demethylation of tri/dimethylated histone H3. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:104047768-104164066

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000004874

ENSBTAP00000004874

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0071558	histone demethylase activity (H3-K27 specific)

Biological Process

GO:0001701	in utero embryonic development
GO:0001843	neural tube closure
GO:0003007	heart morphogenesis
GO:0003016	respiratory system process
GO:0007507	heart development
GO:0010468	regulation of gene expression
GO:0021915	neural tube development
GO:0032525	somite rostral/caudal axis specification
GO:0035264	multicellular organism growth
GO:0048333	mesodermal cell differentiation
GO:0048568	embryonic organ development
GO:0048570	notochord morphogenesis
GO:0060070	canonical Wnt signaling pathway
GO:0071557	histone H3-K27 demethylation
GO:0072358	cardiovascular system development

Cellular Component

GO:0005634	nucleus
GO:0035097	histone methyltransferase complex

Orthologs

Species

Homo sapiens

Mus musculus

Gene ID

Gene Order

ENSG00000147050

View Gene Order

ENSMUSG00000037369

View Gene Order

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_228178

HDMs demethylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

REACT_218274

Chromatin organization pathway

REACT_256030

HDMs demethylate histones pathway

REACT_202766

Chromatin modifying enzymes pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas