Homo sapiens Gene: NAGPA
Summary
InnateDB Gene IDBG-13395.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NAGPA
Gene Name N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000103174
Encoded Proteins
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:5024844-5034141
Strand Reverse strand
Band p13.3
Transcripts
ENST00000312251 ENSP00000310998
ENST00000381955 ENSP00000371381
ENST00000563578 ENSP00000467385
ENST00000566137
ENST00000569296 ENSP00000465949
ENST00000564397
ENST00000561580
ENST00000562037 ENSP00000464994
ENST00000562746 ENSP00000455900
ENST00000569793
ENST00000564922
ENST00000562346 ENSP00000468270
ENST00000591478
ENST00000567739
ENST00000568202
ENST00000565876 ENSP00000465523
ENST00000568528
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 4 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003944 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
GO:0005515 protein binding
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0006464 cellular protein modification process
GO:0006486 protein glycosylation
GO:0006622 protein targeting to lysosome
GO:0007040 lysosome organization
Cellular Component
GO:0016021 integral component of membrane
GO:0032580 Golgi cisterna membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Lysosome pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.21334
RefSeq NM_016256
HUGO
OMIM
CCDS CCDS10527
HPRD 12145
IMGT
EMBL
GenPept
RNA Seq Atlas