Mus musculus Gene: Ect2
Summary
InnateDB Gene IDBG-134125.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ect2
Gene Name ect2 oncogene
Synonyms AI528536; mKIAA4037;
Species Mus musculus
Ensembl Gene ENSMUSG00000027699
Encoded Proteins
ect2 oncogene
ect2 oncogene
ect2 oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114346:
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:27097222-27153878
Strand Reverse strand
Band A3
Transcripts
ENSMUST00000108300 ENSMUSP00000103935
ENSMUST00000108298 ENSMUSP00000103933
ENSMUST00000108296
ENSMUST00000150061 ENSMUSP00000135617
ENSMUST00000124727
ENSMUST00000177055 ENSMUSP00000134744
ENSMUST00000176535 ENSMUSP00000135630
ENSMUST00000176780 ENSMUSP00000134786
ENSMUST00000176242 ENSMUSP00000135740
ENSMUST00000175857 ENSMUSP00000135208
ENSMUST00000176908
ENSMUST00000184113 ENSMUSP00000139341
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 137 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0000910 cytokinesis
GO:0007165 signal transduction
GO:0015031 protein transport
GO:0032147 activation of protein kinase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0032467 positive regulation of cytokinesis
GO:0032862 activation of Rho GTPase activity
GO:0032863 activation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042307 positive regulation of protein import into nucleus
GO:0043065 positive regulation of apoptotic process
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547 positive regulation of GTPase activity
GO:0045666 positive regulation of neuron differentiation
GO:0045859 regulation of protein kinase activity
GO:0051260 protein homooligomerization
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0070301 cellular response to hydrogen peroxide
GO:0070830 tight junction assembly
GO:0071277 cellular response to calcium ion
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0072686 mitotic spindle
GO:0097149 centralspindlin complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
GPCR downstream signaling pathway
Signaling by GPCR pathway
NRAGE signals death through JNK pathway
Signaling by Rho GTPases pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
Signalling by NGF pathway
Signal Transduction pathway
p75 NTR receptor-mediated signalling pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RhoA activity
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.261453 Mm.402068 Mm.405881 Mm.436438
RefSeq NM_001177625 NM_001177626 NM_007900 XM_006535385 XM_006535386
OMIM
CCDS CCDS17270 CCDS50875
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas