InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ect2

Summary

InnateDB Gene

IDBG-134125.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ect2

Gene Name

ect2 oncogene

Synonyms

AI528536; mKIAA4037

Species

Mus musculus

Ensembl Gene

ENSMUSG00000027699

Encoded Proteins

IDBP-264828

ect2 oncogene

IDBP-264830

ect2 oncogene

IDBP-716309

IDBP-717357

IDBP-717656

IDBP-715918

IDBP-717087

IDBP-717847

IDBP-788007

ect2 oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000114346:
The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:27097222-27153878

Strand

Reverse strand

Band

Transcripts

ENSMUST00000108300	ENSMUSP00000103935
ENSMUST00000108298	ENSMUSP00000103933
ENSMUST00000108296
ENSMUST00000150061	ENSMUSP00000135617
ENSMUST00000124727
ENSMUST00000177055	ENSMUSP00000134744
ENSMUST00000176535	ENSMUSP00000135630
ENSMUST00000176780	ENSMUSP00000134786
ENSMUST00000176242	ENSMUSP00000135740
ENSMUST00000175857	ENSMUSP00000135208
ENSMUST00000176908
ENSMUST00000184113	ENSMUSP00000139341

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 137 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	1 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	137 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005096	GTPase activator activity
GO:0005515	protein binding
GO:0017048	Rho GTPase binding
GO:0042803	protein homodimerization activity

Biological Process

GO:0000902	cell morphogenesis
GO:0000910	cytokinesis
GO:0007165	signal transduction
GO:0015031	protein transport
GO:0032147	activation of protein kinase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0032467	positive regulation of cytokinesis
GO:0032862	activation of Rho GTPase activity
GO:0032863	activation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0035556	intracellular signal transduction
GO:0042307	positive regulation of protein import into nucleus
GO:0043065	positive regulation of apoptotic process
GO:0043089	positive regulation of Cdc42 GTPase activity
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547	positive regulation of GTPase activity
GO:0045666	positive regulation of neuron differentiation
GO:0045859	regulation of protein kinase activity
GO:0051260	protein homooligomerization
GO:0051988	regulation of attachment of spindle microtubules to kinetochore
GO:0070301	cellular response to hydrogen peroxide
GO:0070830	tight junction assembly
GO:0071277	cellular response to calcium ion
GO:0071479	cellular response to ionizing radiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0005923	tight junction
GO:0030496	midbody
GO:0032154	cleavage furrow
GO:0072686	mitotic spindle
GO:0097149	centralspindlin complex