Homo sapiens Gene: ECT2
Summary
InnateDB Gene IDBG-65239.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECT2
Gene Name epithelial cell transforming sequence 2 oncogene
Synonyms ARHGEF31;
Species Homo sapiens
Ensembl Gene ENSG00000114346
Encoded Proteins
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
epithelial cell transforming sequence 2 oncogene
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a guanine nucleotide exchange factor and transforming protein that is related to Rho-specific exchange factors and yeast cell cycle regulators. The expression of this gene is elevated with the onset of DNA synthesis and remains elevated during G2 and M phases. In situ hybridization analysis showed that expression is at a high level in cells undergoing mitosis in regenerating liver. Thus, this protein is expressed in a cell cycle-dependent manner during liver regeneration, and is thought to have an important role in the regulation of cytokinesis. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:172750682-172821474
Strand Forward strand
Band q26.31
Transcripts
ENST00000232458 ENSP00000232458
ENST00000366254 ENSP00000391695
ENST00000366090 ENSP00000403446
ENST00000392692 ENSP00000376457
ENST00000417960 ENSP00000415876
ENST00000428567 ENSP00000403501
ENST00000426894 ENSP00000412331
ENST00000415665 ENSP00000412028
ENST00000438041 ENSP00000389108
ENST00000441497 ENSP00000412259
ENST00000444250 ENSP00000411674
ENST00000437296 ENSP00000397788
ENST00000460860
ENST00000486027
ENST00000487073
ENST00000540509 ENSP00000443160
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 151 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 151 [view]
Protein-Protein 151 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004871 signal transducer activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0017048 Rho GTPase binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0000902 cell morphogenesis
GO:0000910 cytokinesis
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0032147 activation of protein kinase activity
GO:0032321 positive regulation of Rho GTPase activity
GO:0032467 positive regulation of cytokinesis
GO:0032862 activation of Rho GTPase activity
GO:0032863 activation of Rac GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0042307 positive regulation of protein import into nucleus
GO:0043065 positive regulation of apoptotic process
GO:0043089 positive regulation of Cdc42 GTPase activity
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0043547 positive regulation of GTPase activity
GO:0045666 positive regulation of neuron differentiation
GO:0045859 regulation of protein kinase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051260 protein homooligomerization
GO:0051988 regulation of attachment of spindle microtubules to kinetochore
GO:0070301 cellular response to hydrogen peroxide
GO:0070830 tight junction assembly
GO:0071277 cellular response to calcium ion
GO:0071479 cellular response to ionizing radiation
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005911 cell-cell junction
GO:0005923 tight junction
GO:0030496 midbody
GO:0032154 cleavage furrow
GO:0072686 mitotic spindle
GO:0097149 centralspindlin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
G alpha (12/13) signalling events pathway
Signalling by NGF pathway
Signaling by Rho GTPases pathway
Signaling by GPCR pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Regulation of RhoA activity
PLK1 signaling events
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.518299 Hs.708375 Hs.741516
RefSeq NM_001258315 NM_001258316 NM_018098 XM_005247180
HUGO
OMIM
CCDS CCDS3220 CCDS58860
HPRD 11860
IMGT
EMBL
GenPept
RNA Seq Atlas