Version 5.4
Mus musculus Gene: Akr1b8
Summary
InnateDB Gene IDBG-134635.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Akr1b8
Gene Name aldo-keto reductase family 1, member B8
Synonyms Fgfrp; Fgrp; FR-1
Species Mus musculus
Ensembl Gene ENSMUSG00000029762
Encoded Proteins
IDBP-134637
aldo-keto reductase family 1, member B8
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000198074:
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 6:34354119-34368463
Strand Forward strand
Band B1
Transcripts
ENSMUST00000038406 ENSMUSP00000040244
ENSMUST00000133370
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004032 alditol:NADP+ 1-oxidoreductase activity
Biological Process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000198074
View Gene Order
ENSBTAG00000001582
Not yet available
Pathways
NETPATH
REACTOME
REACT_189085
Disease pathway
REACT_198569
Retinoid metabolism and transport pathway
REACT_188260
Visual phototransduction pathway
REACT_188257
Signal Transduction pathway
REACT_188255
Diseases associated with visual transduction pathway
KEGG
mmu00051
Fructose and mannose metabolism pathway
mmu00040
Pentose and glucuronate interconversions pathway
mmu00052
Galactose metabolism pathway
mmu00561
Glycerolipid metabolism pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_24968
Retinoid metabolism and transport pathway
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_116125
Disease pathway
KEGG
hsa00052
Galactose metabolism pathway
hsa00040
Pentose and glucuronate interconversions pathway
hsa00051
Fructose and mannose metabolism pathway
hsa00561
Glycerolipid metabolism pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt P45377
TrEMBL
UniProt Splice Variant
Entrez Gene 14187
UniGene Mm.5378
RefSeq NM_008012
OMIM
CCDS CCDS19991
HPRD
IMGT
MGI ID MGI:107673
MGI Symbol Akr1b8
EMBL BC005789 U04204
GenPept AAA16953 AAH05789
RNA Seq Atlas 14187

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca