Homo sapiens Gene: TCF12
Summary
InnateDB Gene IDBG-13567.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TCF12
Gene Name transcription factor 12
Synonyms bHLHb20; CRS3; HEB; HsT17266; HTF4;
Species Homo sapiens
Ensembl Gene ENSG00000140262
Encoded Proteins
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
transcription factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:56918623-57299281
Strand Forward strand
Band q21.3
Transcripts
ENST00000333725 ENSP00000331057
ENST00000267811 ENSP00000267811
ENST00000343827 ENSP00000342459
ENST00000438423 ENSP00000388940
ENST00000558908
ENST00000559609 ENSP00000453876
ENST00000560190
ENST00000557843 ENSP00000453737
ENST00000557947 ENSP00000454109
ENST00000561152 ENSP00000453653
ENST00000561346
ENST00000559216
ENST00000560887
ENST00000561235
ENST00000560764
ENST00000543579 ENSP00000440017
ENST00000537840 ENSP00000444696
ENST00000560506
ENST00000559710 ENSP00000453264
ENST00000559703 ENSP00000454102
ENST00000561420
ENST00000558210
ENST00000561449
ENST00000561454
ENST00000560191
ENST00000560836 ENSP00000454823
ENST00000560948 ENSP00000456280
ENST00000569880
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 37 [view]
Protein-DNA 3 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0035326 enhancer binding
GO:0043425 bHLH transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0007517 muscle organ development
GO:0010628 positive regulation of gene expression
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
ID pathway
REACTOME
Developmental Biology pathway
CDO in myogenesis pathway
Myogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.511504 Hs.595728 Hs.608843 Hs.659471 Hs.682266
RefSeq NM_003205 NM_207036 NM_207037 NM_207038 NM_207040 XM_006720658 XM_006720659
HUGO
OMIM
CCDS CCDS10159 CCDS10160 CCDS42042
HPRD 02725
IMGT
EMBL
GenPept
RNA Seq Atlas