Bos taurus Gene: BT.75685
Summary
InnateDB Gene IDBG-646621.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.75685
Gene Name transcription factor 12
Synonyms
Species Bos taurus
Ensembl Gene ENSBTAG00000002586
Encoded Proteins
transcription factor 12
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000140262:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:53089215-53481049
Strand Reverse strand
Band
Transcripts
ENSBTAT00000035927 ENSBTAP00000035793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0043425 bHLH transcription factor binding
GO:0044212 transcription regulatory region DNA binding
GO:0046332 SMAD binding
GO:0046982 protein heterodimerization activity
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
Biological Process
GO:0010628 positive regulation of gene expression
GO:0045666 positive regulation of neuron differentiation
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
SSD Ortholog
Ortholog supports species divergence
Pathway Predictions based on Human Orthology Data
NETPATH
ID pathway
REACTOME
Developmental Biology pathway
CDO in myogenesis pathway
Myogenesis pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL F1MV33
UniProt Splice Variant
Entrez Gene 509039
UniGene Bt.102082 Bt.75685
RefSeq NM_001077885 XM_005211661
HUGO HGNC:11623
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02028854 DAAA02028855 DAAA02028856 DAAA02028857 DAAA02028858 DAAA02028859 DAAA02028860 DAAA02028861 DAAA02028862 DAAA02028863 DAAA02028864 DAAA02028865
GenPept
RNA Seq Atlas 509039
Transcript Frequencies
Tag Count based mRNA-Abundances across 87 different Tissues (TPM).

Based on Data from Bovine Gene Atlas

Tag Count based mRNA-Abundances across 87 different Tissues (TPM)

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