InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Rps6ka4

Summary

InnateDB Gene

IDBG-136793.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rps6ka4

Gene Name

ribosomal protein S6 kinase, polypeptide 4

Synonyms

1110069D02Rik; 90kDa; AI848992; mMSK2; Msk2

Species

Mus musculus

Ensembl Gene

ENSMUSG00000024952

Encoded Proteins

IDBP-136795

ribosomal protein S6 kinase, polypeptide 4

IDBP-619868

ribosomal protein S6 kinase, polypeptide 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 18690222

[Homo sapiens] Negatively regulates TLR-pathway driven inflammation by preventing the binding of phosphorylated transcription factors CREB and ATF1 to IL-10 and DUSP1 promoters

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162302:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:6829085-6840601

Strand

Reverse strand

Band

Transcripts

ENSMUST00000025903	ENSMUSP00000025903
ENSMUST00000170516	ENSMUSP00000131581

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006468	protein phosphorylation
GO:0006954	inflammatory response
GO:0033129	positive regulation of histone phosphorylation
GO:0035066	positive regulation of histone acetylation
GO:0035556	intracellular signal transduction
GO:0043987	histone H3-S10 phosphorylation
GO:0043988	histone H3-S28 phosphorylation
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0070498	interleukin-1-mediated signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000162302

View Gene Order

ENSBTAG00000039153

Not yet available

Pathways

NETPATH

REACTOME

REACT_257923

Recycling pathway of L1 pathway

REACT_261444

Axon guidance pathway

REACT_219680

L1CAM interactions pathway

REACT_188576

Developmental Biology pathway

KEGG

mmu04010

MAPK signaling pathway pathway

INOH

PID NCI

Pathway Predictions based on Human Orthology Data

NETPATH

REACTOME

REACT_22365

Recycling pathway of L1 pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04010

MAPK signaling pathway pathway

INOH

PID NCI

Cross-References

SwissProt

Q9Z2B9

TrEMBL

UniProt Splice Variant

Entrez Gene

56613

UniGene

Mm.20914 Mm.489625

RefSeq

NM_019924

OMIM

CCDS

CCDS37899

HPRD

IMGT

MGI ID

MGI:1930076

MGI Symbol

Rps6ka4

EMBL

AF074714 AK154674 BC012964

GenPept

AAC67394 AAH12964 BAE32757

RNA Seq Atlas

56613