Mus musculus Gene: Rps6ka4
Summary
InnateDB Gene IDBG-136793.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Rps6ka4
Gene Name ribosomal protein S6 kinase, polypeptide 4
Synonyms 1110069D02Rik; 90kDa; AI848992; mMSK2; Msk2;
Species Mus musculus
Ensembl Gene ENSMUSG00000024952
Encoded Proteins
ribosomal protein S6 kinase, polypeptide 4
ribosomal protein S6 kinase, polypeptide 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
[Homo sapiens] Negatively regulates TLR-pathway driven inflammation by preventing the binding of phosphorylated transcription factors CREB and ATF1 to IL-10 and DUSP1 promoters
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000162302:
This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:6829085-6840601
Strand Reverse strand
Band A
Transcripts
ENSMUST00000025903 ENSMUSP00000025903
ENSMUST00000170516 ENSMUSP00000131581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0033129 positive regulation of histone phosphorylation
GO:0035066 positive regulation of histone acetylation
GO:0035556 intracellular signal transduction
GO:0043987 histone H3-S10 phosphorylation
GO:0043988 histone H3-S28 phosphorylation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0070498 interleukin-1-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Recycling pathway of L1 pathway
Axon guidance pathway
L1CAM interactions pathway
Developmental Biology pathway
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
Developmental Biology pathway
Axon guidance pathway
Recycling pathway of L1 pathway
L1CAM interactions pathway
KEGG
MAPK signaling pathway pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20914 Mm.489625
RefSeq NM_019924
OMIM
CCDS CCDS37899
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas