Version 5.4
Homo sapiens Gene: RPS6KA4
Summary
InnateDB Gene IDBG-53886.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS6KA4
Gene Name ribosomal protein S6 kinase, 90kDa, polypeptide 4
Synonyms MSK2; RSK-B
Species Homo sapiens
Ensembl Gene ENSG00000162302
Encoded Proteins
IDBP-53888
ribosomal protein S6 kinase, 90kDa, polypeptide 4
IDBP-602830
ribosomal protein S6 kinase, 90kDa, polypeptide 4
IDBP-599858
ribosomal protein S6 kinase, 90kDa, polypeptide 4
IDBP-583513
ribosomal protein S6 kinase, 90kDa, polypeptide 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18690222
Negatively regulates TLR-pathway driven inflammation by preventing the binding of phosphorylated transcription factors CREB and ATF1 to IL-10 and DUSP1 promoters
Entrez Gene
Summary This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64359148-64372215
Strand Forward strand
Band q13.1
Transcripts
ENST00000334205 ENSP00000333896
ENST00000528057 ENSP00000435580
ENST00000530383
ENST00000531659
ENST00000528355 ENSP00000435314
ENST00000530504 ENSP00000432945
ENST00000532885
ENST00000532496
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004711 ribosomal protein S6 kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0048273 mitogen-activated protein kinase p38 binding
Biological Process
GO:0001818 negative regulation of cytokine production
GO:0006355 regulation of transcription, DNA-templated
GO:0006468 protein phosphorylation
GO:0006954 inflammatory response
GO:0007411 axon guidance
GO:0009103 lipopolysaccharide biosynthetic process
GO:0016572 histone phosphorylation
GO:0032793 positive regulation of CREB transcription factor activity
GO:0033129 positive regulation of histone phosphorylation
GO:0035066 positive regulation of histone acetylation
GO:0035556 intracellular signal transduction
GO:0043987 histone H3-S10 phosphorylation
GO:0043988 histone H3-S28 phosphorylation
GO:0045087 innate immune response (InnateDB)
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0070498 interleukin-1-mediated signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024952
View Gene Order
ENSBTAG00000039153
Not yet available
Pathways
NETPATH
REACTOME
REACT_22365
Recycling pathway of L1 pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_18266
Axon guidance pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt O75676
TrEMBL A0PJF8
UniProt Splice Variant
Entrez Gene 8986
UniGene Hs.105584
RefSeq NM_003942 XM_005274381 XM_006718735 NM_001006944 NM_001300802 XM_005274379
HUGO HGNC:10433
OMIM 603606
CCDS CCDS8073 CCDS73313
HPRD 04677
IMGT
EMBL AF074715 AJ010119 AK223561 AK292163 BC028079 CH471076
GenPept AAC67395 AAH28079 BAD97281 BAF84852 CAA09009 EAW74260
RNA Seq Atlas 8986

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca