InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Pin1

Summary

InnateDB Gene

IDBG-137359.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pin1

Gene Name

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

Synonyms

0610025L01Rik; D9Bwg1161e

Species

Mus musculus

Ensembl Gene

ENSMUSG00000032171

Encoded Proteins

IDBP-137361

protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21743479

Pin1 is necessary to mount TLR-mediated, interferon-dependent innate and adaptive immune response. Pin1 is activated by Tlr7 and Tlr9, which binds to Irak1 to activate Irf7 which then induce type I interferons.

InnateDB Annotation from Orthologs

Summary

PMID 16699525

[Homo sapiens] PIN1 negatively regulates IRF3-dependent innate antiviral response by binding to phosphorylated IRF3 for proteasome-dependent degradation.

PMID 21743479

[Homo sapiens] PIN1 is necessary to mount TLR-mediated, interferon-dependent innate and adaptive immune response. PIN1 is activated by TLR7 and TLR9, which binds to IRAK1 to activate IRF7 which then induce type I interferons. (Demonstrated in mouse)

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127445:
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer\'s disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:20652130-20666584

Strand

Forward strand

Band

Transcripts

ENSMUST00000034689

ENSMUSP00000034689

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 151 interaction(s) predicted by orthology.

Experimentally validated
Total	25 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	151 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity

Biological Process

GO:0000413	protein peptidyl-prolyl isomerization
GO:0006457	protein folding
GO:0007049	cell cycle
GO:0032465	regulation of cytokinesis
GO:0042127	regulation of cell proliferation
GO:0045087	innate immune response (InnateDB)