InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: PIN1

Summary

InnateDB Gene

IDBG-643081.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIN1

Gene Name

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000016988

Encoded Proteins

IDBP-695606

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 16699525

[Homo sapiens] PIN1 negatively regulates IRF3-dependent innate antiviral response by binding to phosphorylated IRF3 for proteasome-dependent degradation.

PMID 21743479

[Homo sapiens] PIN1 is necessary to mount TLR-mediated, interferon-dependent innate and adaptive immune response. PIN1 is activated by TLR7 and TLR9, which binds to IRAK1 to activate IRF7 which then induce type I interferons. (Demonstrated in mouse)

PMID 21743479

[Mus musculus] Pin1 is necessary to mount TLR-mediated, interferon-dependent innate and adaptive immune response. Pin1 is activated by Tlr7 and Tlr9, which binds to Irak1 to activate Irf7 which then induce type I interferons.

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000127445:
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer\'s disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:15532998-15545250

Strand

Forward strand

Band

Transcripts

ENSBTAT00000022592

ENSBTAP00000022592

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 145 interaction(s) predicted by orthology.

Predicted by orthology
Total	145 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003755	peptidyl-prolyl cis-trans isomerase activity
GO:0005515	protein binding
GO:0016853	isomerase activity
GO:0031434	mitogen-activated protein kinase kinase binding
GO:0032794	GTPase activating protein binding
GO:0050815	phosphoserine binding
GO:0050816	phosphothreonine binding

Biological Process

GO:0001934	positive regulation of protein phosphorylation
GO:0006457	protein folding
GO:0007049	cell cycle
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0032321	positive regulation of Rho GTPase activity
GO:0032465	regulation of cytokinesis
GO:0042127	regulation of cell proliferation
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0060393	regulation of pathway-restricted SMAD protein phosphorylation
GO:0070373	negative regulation of ERK1 and ERK2 cascade
GO:2000146	negative regulation of cell motility